Pathology Outlines - Serous carcinoma
2020年1月30日 · 60 year old woman with adrenal metastasis from uterine serous carcinoma (Am J Case Rep 2016;17:289) 71 year old woman with uterine serous carcinoma with renal and para-aortic metastases (Gynecol Oncol Rep 2019;28:12) Case report and literature review linking uterine serous carcinoma and BRCA mutation (Eur J Cancer 2017;72:215)
Pathology Outlines - Staging-carcinoma and carcinosarcoma
2023年3月1日 · Synchronous endometrial and ovarian endometrioid carcinoma have good prognosis, similar to those with only endometrial or only ovarian stage I cancer (Int J Gynecol Cancer 2014;24:54, Clin Cancer Res 2008;14:5840) Features that support 2 synchronous carcinomas include: Different histologic types or tumor grades
Pathology Outlines - High grade serous carcinoma
2024年6月3日 · 51 year old woman with high grade serous ovarian cancer 3 years after bilateral salpingectomy (Mol Clin Oncol 2017;6:201) 58 year old woman presented with an adnexal mass (Case of the month #538) 73 year old woman with serous carcinoma of the ovary that metastasized to the tail of the pancreas (Mol Clin Oncol 2016;5:41)
Pathology Outlines - Endometrial carcinoma-general
2020年11月23日 · Other associations include diabetes, dysfunctional uterine bleeding, hypertension, infertility, Muir-Torre syndrome, Turner syndrome (usually well differentiated adenocarcinoma; 2/3 have squamous differentiation) and tamoxifen use for breast cancer (increased risk for endometrioid, serous carcinoma and carcinosarcoma) (Am J Surg Pathol …
Pathology Outlines - Carcinosarcoma (MMMT)
2020年12月1日 · Uterus, total hysterectomy and bilateral salpingo-oophorectomy: Uterine carcinosarcoma with a heterologous component (see synoptic report and comment) Comment: There is a malignant biphasic cell proliferation composed of carcinomatous elements: (serous carcinoma) intimately admixed with sarcomatous elements (chondrosarcoma and osteosarcoma).
Pathology Outlines - Uterus
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Pathology Outlines - Clear cell carcinoma
2020年4月21日 · Endometrial serous carcinoma (Am J Surg Pathol 2013;37:874): If p53 abnormal, then serous carcinoma unless completely typical clear cell carcinoma morphology Endometrioid endometrial carcinoma with clear cell or secretory change: Low grade nuclear features, associated atypical hyperplasia, estrogen receptor positive (strong, diffuse)
Pathology Outlines - Endometrioid carcinoma
2020年9月3日 · The Cancer Genome Atlas (TCGA, 2013) defined 4 molecular and prognostic subgroups of endometrial carcinoma (endometrioid (EEC) and serous histotypes) (Nature 2013;497:67): POLE mutated (ultramutated): very high mutational burden, microsatellite stability (~10% of EEC) Comprised by a majority of grade 3 EEC
Pathology Outlines - POLE ultramutated endometrial carcinoma
2023年8月25日 · Uterus, fallopian tubes and ovaries, total hysterectomy and bilateral salpingo-oophorectomy: Endometrial endometrioid carcinoma, FIGO grade 2; final molecular classification: POLE ultramutated (see synoptic report and comment) Tumor invades the inner half of the myometrium ( 50%) Lymphovascular invasion is absent
Mesonephric-like adenocarcinoma (uterus / ovary)
2023年6月1日 · Serous carcinoma: Papillary architectural pattern in association with high grade nuclear atypia Abnormal p53 expression and block-like p16 staining ER and PR not helpful Carcinosarcoma: Solid areas and spindled cell and sarcomatoid features Abnormal p53 expression Absence of KRAS mutations (Cancer Genomics Proteomics 2022;19:747)