Anti-CRISPR - Wikipedia
Anti-CRISPR (Anti-Clustered Regularly Interspaced Short Palindromic Repeats or Acr) is a group of proteins found in phages, that inhibit the normal activity of CRISPR-Cas, the immune system of certain bacteria. [1]
Anti-CRISPRs: Protein Inhibitors of CRISPR-Cas Systems
2020年6月20日 · This review focuses on anti-CRISPRs (Acrs), proteins produced by viruses and other mobile genetic elements that can potently inhibit CRISPR-Cas systems. Discovered in 2013, there are now 54 distinct families of these proteins described, and the functional mechanisms of more than a dozen have been characterized in molecular detail.
Anti-CRISPR protein applications: natural brakes for CRISPR …
2020年3月16日 · The discovery of protein inhibitors of CRISPR-Cas systems, called anti-CRISPR (Acr) proteins, enables the development of more controllable and precise CRISPR-Cas tools. Here we discuss...
Anti-CRISPR: discovery, mechanism and function - Nature
2017年10月24日 · In this Progress article, we discuss recent discoveries that highlight how phages inactivate CRISPR–Cas systems by using anti-CRISPR proteins, and we outline evolutionary and...
Anti-CRISPR protein applications: natural brakes for CRISPR-Cas ...
Anti-CRISPR (Acr) proteins are a collective arsenal of natural bona fide CRISPR-Cas antagonists encoded by diverse MGEs, such as plasmids and phages, that inhibit CRISPR-Cas immune function at various stages 9,10.
Types I and V Anti-CRISPR Proteins: From Phage Defense to …
2020年9月29日 · Anti-CRISPRs are small proteins (approximately, 12–193 amino acids) that confer to phages an efficient and powerful means to nullify the CRISPR-Cas immune system (Liu et al., 2020). CRISPR-Cas systems have been largely used in gene editing and synthetic biology (Wright et al., 2016).
Multiple mechanisms for CRISPR–Cas inhibition by anti-CRISPR proteins
2015年9月23日 · Here we performed biochemical and in vivo investigations of three of these anti-CRISPR proteins, and show that each inhibits CRISPR–Cas activity through a distinct mechanism.
Anti-CRISPRdb v2.2: an online repository of anti-CRISPR proteins ...
2022年3月4日 · Anti-CRISPR proteins (Acrs) are small proteins that can inhibit the activity of CRISPR-Cas (clustered, regularly interspaced short palindromic repeats and CRISPR-associated proteins) systems, which were first reported by Bondy-Denomy et al. in 2013 (1).
Anti-CRISPRs deconstruct bacterial defense - Cell Press
2024年9月5日 · Deploying anti-CRISPR proteins is a potent strategy used by phages to inhibit bacterial CRISPR-Cas defense. In a new Nature paper, Trost et al. discover and characterize an exciting anti-CRISPR mechanism with possible implications beyond this microscopic arms race.
Anti‐CRISPRs: The natural inhibitors for CRISPR‐Cas systems
2019年5月29日 · CRISPR (clustered regularly interspaced short palindromic repeats)‐Cas (CRISPR associated protein) systems serve as the adaptive immune system by which prokaryotes defend themselves against phages. It has also been developed into a series of powerful gene‐editing tools.