Beta-lactamase - Wikipedia
Beta-lactamases (β-lactamases) are enzymes (EC 3.5.2.6) produced by bacteria that provide multi-resistance to beta-lactam antibiotics such as penicillins, cephalosporins, cephamycins, monobactams and carbapenems , although carbapenems are relatively resistant to …
β-Lactamases: Sequence, Structure, Function, and Inhibition
Over the past eight decades, β-lactamases have come into focus as factors of antibiotic resistance. For any β-lactam currently available in the clinic, there is a β-lactamase that can inactivate it.
Beta-Lactam Antibiotics - StatPearls - NCBI Bookshelf
2023年6月4日 · They work primarily by inactivating serine beta-lactamases, which are enzymes that hydrolyze and inactivate the beta-lactam ring (especially in gram-negative bacteria). These agents include the first-generation beta-lactamase inhibitors (clavulanic acid, sulbactam, and tazobactam) and the newer avibactam and vaborbactam that are active against ...
β-Lactamases: A Focus on Current Challenges - PMC - PubMed …
β-Lactamases, the enzymes that hydrolyze β-lactam antibiotics, remain the greatest threat to the usage of these agents. In this review, the mechanism of hydrolysis is discussed for both those enzymes that use serine at the active site and those that require divalent zinc ions for hydrolysis.
Overview of Beta-Lactams - Overview of Beta-Lactams - The Merck …
Beta-lactamases are a diverse class of enzymes produced by bacteria that break open the beta-lactam ring, inactivating the beta-lactam antibiotic. Some beta-lactamases are encoded on mobile genetic elements (eg, plasmids); others are encoded on chromosomes.
The biogenesis of β-lactamase enzymes - PMC
Structural differences between serine β-lactamases (class A, C and D) and metallo-β-lactamases (class B) result in distinct hydrolytic mechanisms that influence the activity spectra of these enzymes, as well as their interaction with β-lactamase inhibitor compounds, developed to attenuate their function and potentiate β-lactam antibiotics.
Beta-Lactamase - an overview | ScienceDirect Topics
Beta-lactamases are genetically and structurally closely related to penicillin-binding proteins. Despite their chemical diversity, their adverse effects profiles share various common aspects. There are several reasons why beta-lactam antibiotics belonging to different classes can cause comparable reactions.
List of Beta-lactamase inhibitors - Drugs.com
Beta-lactamase inhibitors are a class of medicine that block the activity of beta-lactamase enzymes (also called beta-lactamases), preventing the degradation of beta-lactam antibiotics. They tend to have little antibiotic activity on their own.
β-Lactamases: Sequence, Structure, Function, and Inhibition
2021年7月5日 · beta-Lactamase Inhibitors / chemistry* beta-Lactamases* / chemistry beta-Lactamases* / genetics
Beta-Lactamase DataBase (BLDB): Structure and Function
The aim of the Beta-Lactamase DataBase (BLDB) is to compile sequence information as well as biochemical and structural informations on all the currently known β-lactamases. BLDB offers in addition tools to analyze β-lactamases and provides important links to the related web resources (NCBI, PDB, etc.).