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  1. Nature
    https://www.nature.com › articles

    Bone morphogenetic protein 8B promotes the …

    • Non-alcoholic steatohepatitis (NASH) is characterized by lipotoxicity, inflammation and fibrosis, ultimately leading to end-stage liver disease. The molecular mechanisms promoting NASH are poorly un… 展开

    Main

    Non-alcoholic fatty liver disease (NAFLD) is characterized by excessive accumulation of lipids within the liver. The prevalence of NAFLD is high and progressively increasing, espe… 展开

    Nature
    RESULTS

    BMP8B expression is induced in liver injury and NASH
    Levels of Bmp8b mRNA … 展开

    Nature
    Discussion

    The incidence and prevalence of NASH is rising owing to the twin epidemics of obesity and metabolic syndrome. This emerging trend is occurring just as the other great globa… 展开

    Nature
    Methods

    Study population (people with NASH)
    The Cambridge Cohort consisted of 40 consecutive men recruited at the NASH Service at the Cambridge University Hospital. The Ne… 展开

    Nature
    反馈
    目录
    Main
    RESULTS
    Discussion
    Methods
     
  1. GeneCards
    https://www.genecards.org › cgi-bin › car…

    BMP8B Gene - GeneCards | BMP8B Protein | BMP8B …

    2024年10月1日 · GeneCards Summary for BMP8B Gene. BMP8B (Bone Morphogenetic Protein 8b) is a Protein Coding gene. Diseases associated with BMP8B include Laryngeal Tuberculosis and Vestibulocochlear Nerve Disease. …

  2. Nature
    https://www.nature.com › articles

    Adipocyte-secreted BMP8b mediates adrenergic …

    2018年11月26日 · Bmp8b overexpression enhances AT browning and thermogenesis. We generated a transgenic mouse in which expression of the murine Bmp8b gene is under control of the adipocyte-specific...

  3. Bmp8 的研究
  4. Nature
    https://www.nature.com › articles

    Bmp8a is an essential positive regulator of antiviral immunity in ...

  5. Wikipedia
    https://en.wikipedia.org › wiki

    Bone morphogenetic protein 8B - Wikipedia

  6. 知乎专栏
    https://zhuanlan.zhihu.com

    骨形态发生蛋白（BMPs）属于TGF-β超家族，你知道吗？ - 知乎

  7. 其他用户还问了以下问题
    Is BMP8B a gene coding gene?
    The encoded protein stimulates thermogenesis in brown adipose tissue. Expression of this gene may be downregulated in pancreatic cancer. This gene may have arose from a gene duplication event and its gene duplicate is also present on chromosome 1. [provided by RefSeq, Jul 2016] BMP8B (Bone Morphogenetic Protein 8b) is a Protein Coding gene.

    BMP8B Gene - GeneCards | BMP8B Protein | BMP8B Antibody

    genecards.org
    Where is BMP8B protein expressed?
    As observed in rodents, human BMP8B protein is expressed in keratin 18 (KRT18, also known as K18) + hepatocytes and αSMA + HSCs and pericytes (Fig. 1k).

    Bone morphogenetic protein 8B promotes the progression of non-alco…

    nature.com
    How does BMP8A work?
    Evidences supporting this nature of Bmp8a include: Bmp8a inhibits RNA viruses replication in vitro and in vivo; Bmp8a promotes the expression of antiviral protein genes including type I IFNs and mx; the expression of bmp8a is induced by CGRV or poly (I:C), and Bmp8a activates TBK1–IRF3–IFN signaling.

    Bmp8a is an essential positive regulator of antiviral immunity in

    nature.com
    How is BMP8B induced?
    BMP8B is induced by nutritional and thermogenic factors in mature BAT, increasing the response to noradrenaline through enhanced p38MAPK/CREB signaling and increased lipase activity. Bmp8b−/− mice exhibit impaired thermogenesis and reduced metabolic rate, causing weight gain despite hypophagia.

    BMP8B Increases Brown Adipose Tissue Thermogenesis through Both C…

    cell.com
    What diseases are associated with BMP8B?
    Diseases associated with BMP8B include Laryngeal Tuberculosis and Vestibulocochlear Nerve Disease. Among its related pathways are MIF Mediated Glucocorticoid Regulation and TGF-Beta Pathway. Gene Ontology (GO) annotations related to this gene include cytokine activity and transforming growth factor beta receptor binding.

    BMP8B Gene - GeneCards | BMP8B Protein | BMP8B Antibody

    genecards.org
    Should BMP8B be blocked?
    Given that BMP8B is a secreted protein, not required for the normal function of the liver and selectively induced in liver disease, we propose that preventing the induction of BMP8B and/or blocking its extracellular activity could be a safe strategy to limit the progression of NASH and, potentially, of other liver diseases.

    Bone morphogenetic protein 8B promotes the progression of non-alco…

    nature.com
    反馈
  8. National Center for Biotechnology Information
    https://www.ncbi.nlm.nih.gov › gene

    BMP8B bone morphogenetic protein 8b [ Homo sapiens (human) ]

  9. Labcorp
    https://www.labcorp.com › tests

    322758: Metabolic Panel (8), Basic - Labcorp

  10. Cell Press
    https://www.cell.com › cell › fulltext

    BMP8B Increases Brown Adipose Tissue Thermogenesis …

    BMP8B Is Expressed in Mature Brown Adipocytes and Responds to Thermogenic Stimuli. We examined expression levels of Bmp8b and its gene duplicate, Bmp8a, in several murine tissues, and consistent with previous …

  11. ScienceDirect
    https://www.sciencedirect.com › science › article › pii

    Bone morphogenetic proteins (BMPs) in the central ... - ScienceDirect