CD3 (immunology) - Wikipedia
CD3 is a protein complex that activates T cells by binding to the T-cell receptor (TCR) and the CD3-zeta (ζ-chain). CD3 is a useful immunohistochemical marker for T cells and a target for immunosuppressant and cancer therapies.
Mini-review: The T Cell Marker, CD3 Antigen and Antibodies
Learn about the structure, function and expression of CD3, a T cell marker and co-receptor for T cell receptor (TCR) signaling. Find out how anti-CD3 antibodies can be used for T cell activation, proliferation and detection.
CD3-specific antibodies: a portal to the treatment of …
2007年7月20日 · CD3-specific monoclonal antibodies inactivate pathogenic cells by inducing rapid internalization of the T-cell receptor (TCR)–CD3 complex from the cell surface.
Absolute CD 3 - Lab Results explained | HealthMatters.io
Absolute CD 3 is the total number of T-lymphocytes in a blood sample. It includes both CD4+ and CD8+ cells, which have different functions in the immune system. Learn how to interpret your absolute CD 3 result and what it means for your health.
Overcoming the challenges associated with CD3+ T-cell
2021年1月19日 · The development of novel CD3+ T-cell redirectors with the ability to target two tumour antigens is a potential strategy that can be used to overcome tumour antigen escape and restore anti-tumour...
Understanding CD3: A Key Player in Immune Response
2024年6月7日 · CD3 is a protein complex on the surface of T cells that transmits signals from the T cell receptor to the inside of the T cell. Learn how CD3 works, its structure, function, and clinical significance in immunotherapy and diagnostics.
Structures of human γδ T cell receptor–CD3 complex | Nature
2024年4月24日 · These findings reveal organizing principles of the γδ TCR–CD3 complex, providing insights into the unique properties of γδ TCR and facilitating immunotherapeutic interventions.
What is CD3? - Mabtech
CD3 (cluster of differentiation 3) is a T cell co-receptor that plays an important role in T cell activation and signal transduction. The CD3 complex is composed of four chains: two CD3ε, one CD3γ, and one CD3δ chain.
The structural basis of T-cell receptor (TCR) activation: An enduring ...
The T-cell receptor (TCR)–CD3 complex is composed of a diverse αβ TCR heterodimer noncovalently associated with the invariant CD3 dimers CD3ϵγ, CD3ϵδ, and CD3ζζ. The TCR mediates recognition of antigenic peptides bound to MHC molecules (pMHC), whereas the CD3 molecules transduce activation signals to the T cell.
CD3E Gene - CD3 Epsilon Subunit Of T-Cell Receptor Complex
2024年10月1日 · CD3E is a protein coding gene that forms part of the T-cell receptor-CD3 complex, which plays a role in adaptive immune response and T-cell development. Learn about its aliases, disorders, pathways, products, expression, function, localization, and more.