Cell Cycle Arrest - an overview | ScienceDirect Topics
Learn about cell cycle arrest, a process that prevents cell division in response to stress or damage. Find chapters and articles on cell cycle arrest mechanisms, regulation, and senescence in medicine and dentistry.
Putting the brakes on the cell cycle: mechanisms of cellular growth arrest
2021年10月20日 · While the stimuli and mechanisms of cell-cycle arrest are diverse, common principles have emerged. Essential to any form of arrest is inhibition of cyclin-dependent-kinase activity, especially the G1 kinases CDK4 and CDK6, which play a …
Cell cycle control in cancer | Nature Reviews Molecular Cell Biology
2021年9月10日 · In response to DNA damage during interphase, replication stress during S phase or incomplete spindle assembly during M phase, specific cell cycle checkpoints arrest or slow down the cell...
Mechanisms of Cellular Senescence: Cell Cycle Arrest and
2021年3月29日 · Cellular senescence is a stable cell cycle arrest that can be triggered in normal cells in response to various intrinsic and extrinsic stimuli, as well as developmental signals.
The molecular architecture of cell cycle arrest - PMC
We performed hyperplexed imaging of 47 cell cycle effectors to obtain a map of the molecular architecture that governs cell cycle exit and progression into reversible (“quiescent”) and irreversible (“senescent”) arrest states.
Cell-cycle arrest and acute kidney injury: the light and the dark …
Cell-cycle arrest is known to be involved in the pathogenesis of AKI and this ‘dark side’ may also involve progression to chronic kidney disease. However, cell-cycle arrest has a ‘light side’ as well, since this mechanism can protect cells from the disastrous consequences of entering cell division with damaged DNA or insufficient ...
Cell cycle arrest induces lipid droplet formation and confers
2024年1月2日 · Mechanistically, cell cycle arrest induces diacylglycerol acyltransferase (DGAT)–dependent lipid droplet formation to sequester excessive polyunsaturated fatty acids (PUFAs) that...
Cell cycle regulation: p53-p21-RB signaling - Nature
2022年3月31日 · The tumor suppressor p53 can induce cell cycle arrest. Induction of p53 leads to transcriptional downregulation of many cell cycle genes. The cyclin-dependent kinase inhibitor...
The molecular architecture of cell cycle arrest - PubMed
We performed hyperplexed imaging of 47 cell cycle effectors to obtain a map of the molecular architecture that governs cell cycle exit and progression into reversible ("quiescent") and irreversible ("senescent") arrest states.
Cell Cycle Arrest - an overview | ScienceDirect Topics
Learn about cell cycle arrest, a stopping point in the cell cycle that prevents cell division, from various sources of stress or nanoparticles. Find chapters and articles on cell cycle arrest in biochemistry, genetics and molecular biology.
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