Diglyceride - Wikipedia
A diglyceride, or diacylglycerol (DAG), is a glyceride consisting of two fatty acid chains covalently bonded to a glycerol molecule through ester linkages. [1] Two possible forms exist, 1,2-diacylglycerols and 1,3-diacylglycerols.
DAG tales: the multiple faces of diacylglycerol—stereochemistry ...
Diacylglycerol kinases (DGKs) catalyze the formation of PA by phosphorylation of the free hydroxyl (–OH) group of DAG. Together with PAPases/lipins, DGKs are crucially involved in the maintenance of intracellular DAG and PA levels.
Diacylglycerol: Structure, Functions, and Analytical Methods
Diacylglycerol (DAG) is a crucial lipid molecule that plays diverse roles in cellular processes and signaling pathways. It serves as a central intermediate in lipid metabolism, linking various lipid pathways, and modulating key cellular events.
Diacylglycerol - an overview | ScienceDirect Topics
Diacylglycerol (DAG) is an intracellular second messenger that helps to illustrate the potential for second messenger lipidomics. Recently, we linked a genetic abnormality in patients with local aggressive periodontal disease to impaired DAG kinase activity in …
Diacylglycerol, when simplicity becomes complex - Cell Press
Diacylglycerol (DAG) is a simple lipid consisting of a glycerol molecule linked through ester bonds to two fatty acids in positions 1 and 2 (Figure 1). Its small size and simple composition confer exceptional properties on DAG as a lipid intermediate in metabolism, as a component of biological membranes (Box 1), and as a second messenger.
Diacylglycerol - Basic Neurochemistry - NCBI Bookshelf
Protein kinase C is activated by diacylglycerol. The formation of DAG can result in activation of protein kinase C , an enzyme that was first described in the late 1970s. At least ten isoforms of PKC, 70 to 80 kDa, may exist in mammalian tissues [25,26].
Diacylglycerol - an overview | ScienceDirect Topics
Diacylglycerol (DAG) is a lipid present in all eukaryotic cell membranes and has a pivotal role in lipid metabolism and signaling processes that controls several cell function by regulating the localization of protein kinase C (PKC).
Structure and mechanism of human diacylglycerol
2020年5月13日 · The structure of human diacylglycerol O-acyltransferase 1, a membrane protein that synthesizes triacylglycerides, is solved with cryo-electron microscopy, providing insight into its function and...
Structural anatomy of Protein Kinase C C1 domain interactions …
2022年5月16日 · Diacylglycerol (DAG) is a versatile lipid whose 1,2- sn -stereoisomer serves both as second messenger in signal transduction pathways that control vital cellular processes, and as metabolic...
Overarching roles of diacylglycerol signaling in cancer ... - Science
2022年4月12日 · Diacylglycerol (DAG) is a lipid second messenger that is generated in response to extracellular stimuli and channels intracellular signals that affect mammalian cell proliferation, survival, and motility.