Germinal center - Wikipedia
Germinal centers or germinal centres (GCs) are transiently formed structures within B cell zone (follicles) in secondary lymphoid organs – lymph nodes, ileal Peyer's patches, and the spleen [1] – where mature B cells are activated, proliferate, differentiate, and mutate their antibody genes (through somatic hypermutation aimed at achieving ...
Dynamics of B cells in germinal centres - Nature
2015年2月6日 · Bannard, O. et al. Germinal center centroblasts transition to a centrocyte phenotype according to a timed program and depend on the dark zone for effective selection. Immunity 39, 912–924...
Germinal centres: role in B-cell physiology and malignancy
Liu, Y. J. et al. Germinal center cells express BCL-2 protein after activation by signals which prevent their entry into apoptosis. Eur. J. Immunol. 21, 1905–1910 (1991).
Germinal Centers - PubMed
2022年4月26日 · Germinal centers (GCs) are microanatomical sites of B cell clonal expansion and antibody affinity maturation. Therein, B cells undergo the Darwinian process of somatic diversification and affinity-driven selection of immunoglobulins that produces the high-affinity antibodies essential for effective …
Regulation of the Germinal Center Response - PMC
The germinal center (GC) is a specialized microstructure that forms in secondary lymphoid tissues, producing long-lived antibody secreting plasma cells and memory B cells, which can provide protection against reinfection.
Germinal Center B Cell Dynamics: Immunity - Cell Press
Germinal center B cells recognize antigen through a specialized immune synapse architecture
The Biology of the Germinal Center - American Society of …
2007年1月1日 · Many recent avenues of investigation have elucidated that the germinal center is a dynamic microenvironment where B-cells undergo repeated rounds of mutation and selection.
The unique biology of germinal center B cells - Cell Press
2021年8月10日 · Germinal center (GC) B cells are the source of the high-affinity, class-switched antibodies required for protective immunity. The unique biology of GC B cells involves iterative rounds of antibody gene somatic hypermutation coupled …
Germinal Center Organization and Cellular Dynamics - PMC
Germinal center initiation, variable gene region hypermutation, and mutant B cell selection without detectable immune complexes on follicular dendritic cells. J Exp Med. 2000;192:931–942. doi: 10.1084/jem.192.7.931.
Compartments and Connections Within the Germinal Center
2021年3月31日 · Germinal Center Initiation. Activation of naïve B cells in primary follicles induces migration to interfollicular areas and conjugates with antigen-specific T cells. B cells then present antigens to T cells and receive help through CD40-CD40L …
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