T cell responses to cytomegalovirus - Nature Reviews Immunology
2016年4月25日 · In this Review, we describe the features of CD8 + T cell responses to HCMV and draw on data from animal models to help define the mechanisms underlying memory inflation. We discuss how such...
Cytomegalovirus (CMV)-specific cytotoxic T lymphocyte therapy …
2021年10月20日 · First-line therapy with donor-derived human cytomegalovirus (HCMV)-specific T cells reduces persistent HCMV infection by promoting antiviral immunity after allogenic stem cell...
Human Cytomegalovirus (HCMV)-Specific CD4+ T Cells Are …
2017年2月28日 · Human cytomegalovirus (HCMV) infection and periodic reactivation are generally well controlled by the HCMV-specific T cell response in healthy people. While the CD8<sup>+</sup> T cell response to HCMV has been extensively studied, the HCMV-specific CD4<sup>+</sup> T cell effector response is not as …
Human Cytomegalovirus (HCMV)-Specific CD4+ T Cells Are …
2017年3月3日 · Identification of HCMV-specific CD4 + T cells has mainly been by measurement of intracellular cytokine production, predominantly gamma interferon (IFN-γ) production in response to stimulation; these studies have shown strong responses to both the pp65 and IE proteins of the virus (see the work summarized in references 3, 4, and 14).
Identification of HCMV-derived T cell epitopes in seropositive ... - PubMed
2020年3月2日 · Multiple HCMV-directed specificities in the memory T cell pool of single individuals indicate that physiologic anti-HCMV T cell responses are directed against a broad range of antigens. Thus, the unbiased identification of naturally presented viral epitopes enabled a comprehensive and systematic assessment of the physiological repertoire of ...
Transcriptional signature of durable effector T cells elicited by a ...
2024年4月1日 · We demonstrated that V160 de novo induces IE-1 and pp65 specific durable polyfunctional effector CD8 T cells that are comparable to those induced by natural HCMV infection.
Single-cell transcriptomic and T cell antigen receptor analysis of ...
Here, in an unbiased manner, we characterized over 8000 hCMV-reactive peripheral memory T cells isolated from seropositive human donors, at a single-cell resolution by analysing their single-cell transcriptomes paired with the T cell antigen receptor (TCR) repertoires.
Human Cytomegalovirus (HCMV) - specific T-cell response after ...
2023年8月1日 · The aim of this study was to evaluate the role of HCMV-specific T-cell response measured at the end of the LTV administration in predicting clinically significant HCMV infection after prophylaxis. To better characterize HCMV-specific T-cell response, whole HCMV antigen and a peptide pool of protein pp65 were used.
Prospects of Cytomegalovirus-Specific T-Cell Receptors in …
2023年6月7日 · Studying specific T-cells and their TCR repertoire could aid in the identification of potential diagnostic biomarkers and the development of safe and effective immunotherapies. This, in turn, offers a reliable foundation for the clinical application of adoptive immunotherapy with HCMV-specific T-cells and TCR T-cells. Figure 1.
Human cytomegalovirus UL23 exploits PD-L1 inhibitory signaling …
2024年6月3日 · Herein, we present compelling evidence that UL23 significantly enhances viral resistance against T cell-mediated cytotoxicity during HCMV infection from the co-culture assays of HCMV-infected cells with T cells. We found that IFN-γ plays a major role in regulating T cell cytotoxicity mediated by UL23.