IL-17 family: cytokines, receptors and signaling - PubMed
The IL-17 family signals via their correspondent receptors and activates downstream pathways that include NFκB, MAPKs and C/EBPs to induce the expression of anti-microbial peptides, cytokines and chemokines.
Interleukin 17 Family Cytokines: Signaling Mechanisms, Biological ...
The canonical IL-17 signaling pathway initiates signaling through Act1-induced K63-linked ubiquitylation of TRAF6, thereby activating the mitogen-activated protein kinase (MAPK), CCAAT-enhancer-binding protein β (C/EBPβ), and nuclear factor κB (NF-κB) pathways.
Basic biology and role of interleukin-17 in immunity and inflammation
Ligand-induced IL-17 receptor signaling initiates the recruitment of the essential adaptor molecule Act1, which in turn recruits tumor necrosis factor-R-associated factor 6 (TRAF6), a critical upstream activator of the NF-κB pathway.
The IL-17 family in diseases: from bench to bedside
2023年10月11日 · In this paper, we review the latest findings on the IL-17 signaling pathway and comprehensively analyze and present its synergistic effect with other signaling molecules.
IL-17 receptor-based signaling and implications for disease
The integration of IL-17 with growth-receptor signaling in specific cell types offers new understanding of the mitogenic effect of IL-17 on tissue repair and cancer. This Review summarizes new developments in IL-17 signaling and their pathophysiological implications.
IL-17 signaling pathway - Homo sapiens (human) - GenomeNet
IL-17A, the hallmark cytokine of the newly defined T helper 17 (TH17) cell subset, has important roles in protecting the host against extracellular pathogens, but also promotes inflammatory pathology in autoimmune disease, whereas IL-17F is mainly involved in …
The IL-17 family in diseases: from bench to bedside - PubMed
2023年10月11日 · This review discusses recent progress in understanding the IL-17 signaling pathway and its physiological roles. In addition, we present the mechanism underlying IL-17's role in various pathologies, particularly, in IL-17-induced systemic lupus erythematosus and IL-17-related tumor cell transformation and metastasis.
An Overview of IL-17 Function and Signaling - PMC - National …
Because the IL-17 receptor family is distinct in sequence from other cytokine family, studies defining its signaling mechanisms have lagged behind other cytokine families. Early studies showed that IL-17 could activate NF-κB and MAPK pathways, which was not surprising given the pro-inflammatory nature of IL-17 target genes (Table 2, ).
Frontiers | Biology of Interleukin-17 and Its Pathophysiological ...
2020年7月27日 · In the current review, we summarize the biological functions of IL-17, including IL-17-mediated responses and signal transduction pathways, with particular emphasis on clinical relevance to sepsis. Introduction. The interleukin (IL)-17 family includes six structure-related cytokines (A–F; Figure 1).
The IL-17 Family of Cytokines in Health and Disease
2019年4月16日 · Post-transcriptional control of mRNA is central to IL-17 signaling, because numerous canonical IL-17 target genes, particularly chemokine and cytokine genes (e.g., Cxcl1, Cxcl5, Il6), are encoded by intrinsically unstable transcripts (Amatya …
- 某些结果已被删除