Job Syndrome - StatPearls - NCBI Bookshelf
2023年8月28日 · Job Syndrome (Hyper-IgE syndrome) is a rare, primary immunodeficiency distinguished by the clinical triad of atopic dermatitis, recurrent skin staphylococcal infections, and recurrent pulmonary infections. The disease is characterized by elevated IgE levels with an early onset in primary childhood.
Hyper IgE Syndrome (Job's Syndrome) | Symptoms & Treatment
Hyper IgE syndrome is an immune deficiency caused by a genetic mutation in either STAT3 (autosomal dominant, also known as Job’s syndrome) or DOCK8 (autosomal recessive). There may be other mutations in other genes that are not known at this time.
Hyperimmunoglobulin E syndrome - Wikipedia
Autosomal dominant Hyper-IgE Syndrome caused by STAT3 defects, called Job Syndrome, have characteristic facial, dental, and skeletal abnormalities. Patients with STAT3 HIES may have either delay of or failure in shedding of primary teeth. …
Autosomal dominant hyper-IgE syndrome - MedlinePlus
Autosomal dominant hyper-IgE syndrome (AD-HIES), formerly known as Job syndrome, is a condition that affects several body systems, particularly the immune system. Explore symptoms, inheritance, genetics of this condition.
Job syndrome (hyper-IgE syndrome) - DermNet
Job syndrome, also called hyper- IgE syndrome, is the name given to a rare inherited immune deficiency characterised by severe infections of the skin and other organs. What are the clinical features of Job syndrome? Clinical features of Job syndrome include: High levels of eosinophils in the blood. What is the cause of Job syndrome?
Job Syndrome: Symptoms, Causes & Treatment - Medicover …
Job Syndrome, also known as Hyper-IgE Syndrome (HIES), is a rare immunodeficiency disorder characterized by elevated levels of immunoglobulin E (IgE) and a range of symptoms affecting multiple systems in the body.
Job Syndrome: Practice Essentials, Background, Pathophysiology - Medscape
2021年11月10日 · Autosomal dominant hyper-IgE syndrome (AD-HIES), formerly known as Job syndrome, is a rare syndrome that includes the triad of eosinophilia, eczema, and recurrent skin and pulmonary...
Hyperimmunoglobulin E syndrome - MedlinePlus
Hyperimmunoglobulin E syndrome is also called Job syndrome. It is named after the biblical character Job, whose faithfulness was tested by an affliction with draining skin sores and pustules. People with this condition have long-term, severe skin infections.
STAT3 Dominant-Negative Disease - National Institute of …
STAT3 dominant-negative disease (STAT3DN)—also known as autosomal dominant hyper-IgE syndrome (AD-HIES) or Job’s Syndrome—results from mutations in the gene that encodes a signaling protein called STAT3.
Hyperimmunoglobulin E syndrome - Mount Sinai Health System
Hyperimmunoglobulin E syndrome is also called Job syndrome. It is named after the biblical character Job, whose faithfulness was tested by an affliction with draining skin sores and pustules. People with this condition have long-term, severe skin infections.