Orexin receptor - Wikipedia
The orexin receptor (also referred to as the hypocretin receptor) is a G-protein-coupled receptor that binds the neuropeptide orexin. There are two variants, OX 1 and OX 2, each encoded by a different gene (HCRTR1, HCRTR2). [1]
Orexins: Understanding Its Role in Sleep | Sleep Foundation
2023年12月22日 · Dual orexin receptor antagonists (DORAs) are a new type of prescription sleep aid that targets the body’s orexin system. These medications work by acting as orexin receptor antagonists, meaning that they block the effects of orexins in the body, reduce the drive to stay awake, and facilitate sleep.
Frontiers | The Orexin/Receptor System: Molecular Mechanism …
2018年6月27日 · Orexins, also known as hypocretins, are two neuropeptides secreted from orexin-containing neurons, mainly in the lateral hypothalamus (LH). Orexins orchestrate their effects by binding and activating two G-protein–coupled receptors (GPCRs), orexin receptor type 1 (OX1R) and type 2 (OX2R).
Evolution of Orexin Neuropeptide System: Structure and Function
Orexins are hypothalamic neuropeptides that were initially identified in the rat brain as endogenous ligands for an (previously) orphan G-protein-coupled receptor (GPCR). They are multitasking peptides involved in many physiological functions, ...
Orexin System: The Key for a Healthy Life - PMC
The actions of orexins are mediated via two G protein-coupled receptors named orexin-1 (OX 1 R) and orexin-2 (OX 2 R) receptors. OX 1 R is selective for orexin A, whereas OX 2 R is a non-selective receptor for both orexin A and orexin B. OX 1 R is coupled exclusively to the Gqsubclass of heterotrimeric G proteins, whereas OX 2 R couples to Gi ...
The physiological role of orexin/hypocretin neurons in the …
Orexins (also known as hypocretins) were identified as endogenous ligands for two orphan G-protein-coupled receptors in the lateral hypothalamic area. They were initially recognized as regulators of feeding behavior, but they are mainly regarded as key modulators of the sleep/wakefulness cycle.
The Orexin/Receptor System: Molecular Mechanism and …
2018年6月28日 · Orexins, also known as hypocretins, are two neuropeptides secreted from orexin-containing neurons, mainly in the lateral hypothalamus (LH). Orexins orchestrate their effects by binding and activating two G-protein-coupled receptors (GPCRs), orexin receptor type 1 (OX1R) and type 2 (OX2R).
The Orexin receptors: Structural and anti-tumoral properties
2022年7月28日 · The orexins/OX receptors system play an important role in the central and peripheral nervous system where it controls wakefulness, addiction, reward seeking, stress, motivation, memory, energy homeostasis, food intake, blood pressure, hormone secretions, reproduction, gut motility and lipolysis.
Orexin Receptor - an overview | ScienceDirect Topics
Orexin (hypocretin) containing neurons reside in discrete regions of the lateral hypothalamus from where they innervate the entire neuroaxis. Via actions upon orexin receptors (OX1 and OX 2), the orexin peptides (orexin A and orexin B) are thought to play a …
The role of orexin in motivated behaviours - Nature
2014年10月10日 · Orexin receptor type 2 (OX2R) has been thought to have a major role in maintaining wakefulness, but orexin receptor type 1 (OX1R) is likely to be involved in a broad range of functions, including...