Osteoclastogenesis - an overview | ScienceDirect Topics
Osteoclastogenesis is a complex process that initiates with the differentiation of common myeloid progenitors into monocytes. In response to osteoclastogenic stimuli, monocytes can migrate …
Osteoclastogenesis and Osteogenesis - PMC
This Special Issue of the International Journal of Molecular Sciences presents recent advances in our understanding of the molecular mechanisms underlying osteoclastogenesis and …
Osteoclasts: What Do They Do and How Do They Do It? - PMC
The osteoclast is a member of the monocyte/macrophage family that differentiates under the aegis of two critical cytokines, namely RANK ligand and M-CSF. Tumor necrosis factor (TNF) …
Osteoclastogenesis--current knowledge and future perspectives
In osteoporosis, this balance shifts in favor of osteoclasts, and bone resorption exceeds bone formation. More detailed knowledge of the biology of osteoclasts and osteoclastogenesis has …
Osteoclastogenesis - an overview | ScienceDirect Topics
Osteoclastogenesis is a complex multi-step process where myeloid cells/macrophages are first committed as osteoclasts precursors near the bone surface. Osteoclasts differentiation …
Osteoclastogenesis - an overview | ScienceDirect Topics
Osteoclastogenesis is a complex process that initiates with the differentiation of common myeloid progenitors into monocytes. In response to osteoclastogenic stimuli, monocytes can migrate …
Osteoclast differentiation and activation | Nature
2003年5月15日 · Discovery of the RANK signalling pathway in the osteoclast has provided insight into the mechanisms of osteoclastogenesis and activation of bone resorption, and how …
The Cell Origin and Role of Osteoclastogenesis and …
In this review, we have summarized the current findings on the origin and functions of osteoblast-like and osteoclast-like cells in the development and progression of vascular progression, and …
Unraveling the intricacies of osteoclast differentiation and …
2024年2月1日 · During osteoclast differentiation, an osteoclast undergoes various changes, including changes in gene expression patterns, morphology, and metabolic processes. The …
Genetic regulation of osteoclast development and function
2003年8月1日 · In the past five years, remarkable progress has been made in dissecting the molecular mechanisms of osteoclastogenesis and bone degradation, which largely reflects the …
Osteoclastogenesis and Osteogenesis - MDPI
2022年6月15日 · This Special Issue of the International Journal of Molecular Sciences presents recent advances in our understanding of the molecular mechanisms underlying …
Osteoclasts: New Insights | Bone Research - Nature
2013年3月29日 · Osteoclasts, the bone-resorbing cells, play a pivotal role in skeletal development and adult bone remodeling. They also participate in the pathogenesis of various bone disorders.
Mechanisms involved in normal and pathological osteoclastogenesis
In this review, we provide an overview of signaling pathways and other regulatory elements governing osteoclastogenesis. We also identify how osteoclastogenesis is altered in …
Macrophage-Osteoclast Associations: Origin, Polarization, and …
Osteoclastogenesis is promoted via TNF-α both directly by increasing OCP population and/or differentiation, and indirectly by enhancing RANKL secretion in osteoblasts and other cells (64, …
Osteoclast biology in the single-cell era | Inflammation and ...
2022年9月2日 · Recent studies using single-cell technologies have uncovered the regulatory mechanisms underlying osteoclastogenesis at unprecedented resolution and shed light on the …
STAT3-mediated osteogenesis and osteoclastogenesis in …
2022年7月25日 · Osteoclastogenesis is a complex process that includes the regulation of various cytokines and the cell–cell fusion of osteoclast precursors. RANKL and macrophage-colony …
Stepwise cell fate decision pathways during osteoclastogenesis at ...
2020年12月7日 · Using single-cell RNA sequencing, Tsukasaki et al. provide a comprehensive road map of osteoclastogenesis, unveiling stepwise molecular events underlying osteoclast …
Current perspectives on the multiple roles of osteoclasts ... - eLife
2024年4月9日 · Osteoclast SrGAP2 intracellularly binds the SLIT3/ROBO complex and inhibits Rac1 GTPase, resulting in the inhibition of TNF-α-mediated osteoclastogenesis. The pathway …
Role of OSCAR Signaling in Osteoclastogenesis and Bone Disease
Osteoclast-associated receptor (OSCAR), a regulator of osteoclast differentiation, provides one such co-stimulatory pathway. This review summarizes our present knowledge of …
Full article: Inhibition of EGFR Pathway Suppresses M1 …
5 天之前 · Osteoclastogenesis is a complex process further regulated by epidermal growth factor receptor (EGFR) signaling. EGFR, a widely expressed member of the ErbB receptor family of …