Plasmodium Sporozoite Biology - PMC - National Center for ...
The Plasmodium sporozoite constitutes the first form of the malaria parasite entering the human body and, hence, provides the first and leading targets to control an infection. Only few (∼10–100) sporozoites are injected by infected mosquitoes, suggesting …
CDC - DPDx - Malaria
There are approximately 156 named species of Plasmodium which infect various species of vertebrates. Four species are considered true parasites of humans, as they utilize humans almost exclusively as a natural intermediate host: P. falciparum, P. vivax, P. ovale and P. malariae.
Plasmodium sporozoites on the move: Switching from cell ...
2020年12月5日 · Plasmodium sporozoites, the mosquito‐transmitted forms of the malaria parasite, traverse multiple cells during their migration from the skin to the liver, before switching to productive invasion of a suitable hepatocyte for replication.
Plasmodium—a brief introduction to the parasites causing ...
2021年1月7日 · Unlike the Plasmodium species that infect mammals, avian malaria parasites develop and produce infectious sporozoites in non-anopheline mosquitoes. This implies that mammalian Plasmodium species also could acquire resistance to the immune system of non-anopheline mosquitoes such as Culex and Aedes and use them as transmission vectors.
Plasmodium Sporozoite Biology - PubMed
2017年5月1日 · Sporozoites colonize mosquito salivary glands, migrate through the skin, penetrate blood vessels, breach the liver sinusoid, and invade hepatocytes. Understanding the molecular and cellular mechanisms that mediate the remarkable sporozoite journey in the invertebrate vector and the vertebrate host can inform evidence-based next-generation drug ...
The silent path to thousands of merozoites: the Plasmodium ...
2006年11月1日 · Plasmodium sporozoites (green) are deposited under the skin of the vertebrate host through the bite of an infected female Anopheles mosquito. After injection into the skin, the sporozoites move...
The Plasmodium sporozoite journey: a rite of passage - Cell Press
Sporozoites are the most versatile of the invasive stages of the Plasmodium life cycle. During their passage within the mosquito vector and the vertebrate host, sporozoites display diverse behaviors, including gliding locomotion and invasion of, …