Polyamine - Wikipedia
A polyamine is an organic compound having more than two amino groups. Alkyl polyamines occur naturally, but some are synthetic. Alkylpolyamines are colorless, hygroscopic, and water soluble. Near neutral pH, they exist as the ammonium derivatives. [1] Most aromatic polyamines are crystalline solids at room temperature.
Polyamines: their significance for maintaining health and …
2023年12月4日 · This review examines a variety of topics, such as polyamine source and metabolism, including metabolism, transport, and the potential impact of polyamines on health and disease. In addition, a brief summary of the effects of oncogenes and signaling pathways on tumor polyamine metabolism is provided.
Polyamines: Functions, Metabolism, and Role in Human …
2021年6月9日 · Putrescine, spermine, and spermidine are the important polyamines (PAs), found in all living organisms. PAs are formed by the decarboxylation of amino acids, and they facilitate cell growth and development via different cellular responses. PAs are the integrated part of the cellular and genetic meta ….
Polyamines and Their Metabolism: From the Maintenance of …
2022年7月15日 · Introduction. Polyamines are aliphatic polycations that are present in all cells and play an important role in the mediation of biological functions that are necessary for growth and survival [1, 2]. Their discovery dates back to 1678, when spermine was first identified as crystals in cooled human sperm [3].
PubMed Central (PMC)
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Polyamine metabolism and cancer: treatments, challenges and …
2018年9月4日 · This Review discusses new insights into molecular mechanisms that link the dysregulation of polyamine metabolism with carcinogenesis and strategies for targeting this pathway for cancer therapy.
Biogenic Polyamines and Related Metabolites - PMC
2021年12月22日 · Polyamine metabolism is maintained by several enzymes. Diamine putrescine, the precursor of spermidine and spermine, is produced from a non-proteinogenic amino acid ornithine of the urea cycle by ornithine decarboxylase (ODC), which is a rate-limiting polyamine biosynthetic enzyme.
Recent Advances in the Synthesis of Polyamine Derivatives and …
2021年10月30日 · Several synthetic approaches to obtaining analogs and conjugates of PAs are known. The optimal synthetic strategy depends on the structure of the desired molecules. In this review, we describe and analyze various approaches that have been used in the synthesis of polyamines and their conjugates.
Biochemical and pathophysiological properties of polyamines
2020年2月18日 · The manuscripts project the role of polyamines in cell growth and differentiation, cell cycle regulation, gene expression, and signal transduction in animals, plants, and microorganisms as well as under several pathophysiological processes including carcinogenesis and other diseases.
Modular biocatalysis for polyamines | Nature Catalysis
2021年6月21日 · Polyamines are a ubiquitous and diverse class of natural products with unique functional traits. Although their full biological roles still require further elucidation, polyamines are...