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  1. ScienceDirect
    https://www.sciencedirect.com/science/article/pii/B9780123852458000042

    The B Cell Receptor: Proteins and Genes - ScienceDirect

    • Immunoglobulins (Igs) are antigen-binding proteins produced by B cells. Igs contain two identical heavy (H) chains and two identical light (L) chains. Each H chain associates with an L chain to form an antigen-bi… 展开

    Keywords

    immunoglobulin
    antibody
    isotype
    V(D)J recombination
    gene … 展开

    ScienceDirect
    A. Immunoglobulin Proteins

    I. The Nature of Immunoglobulin Proteins
    How did antibodies and immunoglobulins get their names? In the late 1800s, scientists discovered that the serum component of bl… 展开

    ScienceDirect
    B. Immunoglobulin Genes

    The antibody repertoire produced over an individual’s lifetime includes specificities for essentially any antigen in the universe. How does the plasma cell population produce this plet… 展开

    ScienceDirect
    Focus on Relevant Research

    “Generating Recombinant Antibodies to the Complete Human Proteome” by Dübel, S., Stoevesandt, O., Taussig, M.J., and Hust, M. (2010) Trends in Biotechnology 7, 333–339.… 展开

    ScienceDirect
    C. Antibody–Antigen Interaction

    I. Structural Requirements
    Whether an Ig protein is membrane-fixed as part of the BCR complex or free as a soluble antibody, it is folded so that the CDRs of both V… 展开

    ScienceDirect
    Is IgD a membrane-bound Ig?
    Subsequently, the finding that it also exists as a membrane-bound Ig stimulated a large number of studies during the 70s. Then, the interest on IgD shrank, largely because of the lack of known function of secretory IgD (secIgD) and of a stagnating knowledge of the functions of surface IgD.
    pubmed.ncbi.nlm.nih.gov
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    目录
    Keywords
    A. Immunoglobulin Proteins
    B. Immunoglobulin Genes
    Focus on Relevant Research
    C. Antibody–Antigen Interaction
    Is IgD a membrane-bound Ig?
     
  1. Membrane-bound Ig (mIg) is part of the B cell receptor (BCR), soluble Ig (sIg) is secreted by plasma cells as antibody, and secretory antibodies (SIg) are polymeric sIg forms found in secretions.
    了解详细信息：
    Membrane-bound Ig (mIg) is part of the B cell receptor (BCR), soluble Ig (sIg) is secreted by plasma cells as antibody, and secretory antibodies (SIg) are polymeric sIg forms found in secretions.

    The B Cell Receptor: Proteins and Genes …

    www.sciencedirect.com/science/article/pii/B978012…
    Immunoglobulins can exist in 2 forms: secreted immunoglobulin (sIg) and membrane-bound immunoglobulin (mIg).

    Membrane-bound Immunoglobulins an…

    medium.com/biotechnology-by-tsb/membrane-bou…
  2. ScienceDirect
    https://www.sciencedirect.com/science/article/pii/S0161589001000062

    Structural and functional properties of membrane and secreted IgD

  3. Medium
    https://medium.com/biotechnology-by-tsb/m…

    Membrane-bound Immunoglobulins and B-cell …

    2022年5月25日 · Immunoglobulins can exist in 2 forms: secreted immunoglobulin (sIg) and membrane-bound immunoglobulin (mIg). The five classes of antibodies IgG, IgA, IgD, IgE, and IgM can be expressed either...

  4. Nature
    https://www.nature.com/articles/s41586-022-05412-7

    Structural principles of B cell antigen receptor assembly

  5. Nature
    https://www.nature.com/articles/ncomms13600

    Mature IgM-expressing plasma cells sense antigen and develop …

  6. secreted and Membrane-bound Ig的图片

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  7. nih.gov
    https://pmc.ncbi.nlm.nih.gov/articles/PMC6803036

    Secreted IgM: New Tricks for an Old Molecule - PMC

  8. Nature
    https://www.nature.com/articles/cr201465

    No receptor stands alone: IgG B-cell receptor intrinsic …

    2014年5月20日 · The BCR is composed of a membrane-bound form of immunoglobulin (mIg) and a covalently-linked heterodimer of Igα and Igβ in a 1:1 ratio of mIg:Igα/Igβ heterodimer .

  9. American Association of Immunologists
    https://journals.aai.org/jimmunol/article/1…

    Conveying the Message: Identification of Ig-α and Ig-β …

    2009年8月1日 · In an accompanying paper, the Reth laboratory identified the protein missing from plasmacytoma cells as B34, a 34-kDa disulfide-linked glycoprotein associated with membrane-bound IgM . 558LμM cells were …

  10. PubMed
    https://pubmed.ncbi.nlm.nih.gov/11282392

    Structural and functional properties of membrane and secreted IgD

  11. Cell Press
    https://www.cell.com/fulltext/0092-8674(80)90476-6

    The immunoglobulin μ chains of membrane-bound and secreted …