Calciphylaxis (calcific uremic arteriolopathy) - UpToDate
Feb 16, 2024 · There is no approved treatment for calciphylaxis. Calciphylaxis most commonly occurs in patients who have end-stage kidney disease (ESKD) and are on dialysis [2-4] but may also occur in kidney transplant recipients [4] and in non-ESKD patients [5,6].
Sodium Thiosulfate for Calciphylaxis Treatment in Patients on ...
Limited data are available on the utilization of sodium thiosulfate (STS) treatment for calciphylaxis in peritoneal dialysis (PD) patients, while it is well-studied in hemodialysis (HD) patients.
Intravenous Sodium Thiosulphate for Calciphylaxis of Chronic Kidney Disease
A 2022 meta-analysis of 6 clinical trials 2 concluded that intravenous sodium thiosulfate (STS) could attenuate the progression of macrovascular calcification (in the coronary and iliac arteries) among hemodialysis patients.
the estimated enrollment is around 110 patients undergoing dialysis with calciphylaxis associated pain. Its purpose is to evaluate the efficacy and safety of intravenous administration of 25 grams of sodium thiosulfate at the end of each hemodialysis session (3 times weekly) during a …
Calciphylaxis - Diagnosis and treatment - Mayo Clinic
Jul 9, 2024 · A medicine called sodium thiosulfate can lower calcium buildup in the small arteries. It's given through a needle in a vein three times a week, usually during dialysis. Your healthcare professional may recommend that you take a medicine called cinacalcet (Sensipar), which can help control parathyroid hormone (PTH).
Calciphylaxis: Risk Factors, Diagnosis, and Treatment - PMC
-Intravenous sodium thiosulfate at doses ranging from 12.5 to 25 grams in the last 30 minutes of each hemodialysis session for patients on 3 times a week dialysis schedule. 47 For patients with other hemodialysis prescriptions dose adjustments …
Sodium thiosulfate is an injectable solution that is being developed to treat calciphylaxis-associated pain in patients undergoing dialysis. It is thought that sodium thiosulfate works by attaching itself to the calcium to form a compound that is removed from the body in the urine, reducing the build-up of calcium in the arteries.
Sodium Thiosulfate and the Anion Gap in Patients Treated by Hemodialysis
Of 35 study patients, 33 (94%) had an increase in mean anion gap while on STS treatment compared to the anion gap immediately before treatment . In several patients, the increase in mean anion gap was extreme, with increases up to 18 mmol/L (fig a of Item S1).
INDEX WORDS: Calciphylaxis; sodium thiosulfate; technetium bone scan; peritoneal dialysis (PD). CALCIPHYLAXIS (or calcific uremic arte-riolopathy) is an uncommon but dreaded complication of renal failure characterized by nodular or plaquelike subcutaneous calcification and painful tissue necrosis often leading to ulcer-
Intravenous sodium thiosulphate for vascular calcification of ...
Intravenous STS may attenuate the progression of VC and arterial stiffness in hemodialysis patients. Large and well-designed randomized controlled trials are warranted. Keywords: arterial stiffness, bone mineral density, chronic kidney disease, sodium thiosulphate, vascular calcification. Graphical Abstract. KEY LEARNING POINTS.