Understanding Asthma Phenotypes, Endotypes, and Mechanisms …
Asthma endotypes may be broadly regarded as type 2 (T2) high or T2-low. Several biologic agents have been approved for T2-high asthma, with numerous other therapeutics that are incipient and similarly targeted at specific molecular mechanisms.
Th2 responses: T helper 2 cells in asthma - PMC - National Center …
2023年6月6日 · This review provides an update of our current understanding of Th2 cells in human asthma, highlighting their many guises and functions in asthma, both pathogenic and regulatory, and how these are influenced by the tissue location and disease stage and severity.
The basic immunology of asthma - PubMed
2021年3月18日 · In many asthmatics, chronic airway inflammation is driven by IL-4-, IL-5-, and IL-13-producing Th2 cells or ILC2s. Type 2 cytokines promote hallmark features of the disease such as eosinophilia, mucus hypersecretion, bronchial hyperresponsiveness (BHR), IgE production, and susceptibility to exacerba ….
Th2 Responses: Type 2 inflammation and biological therapies in asthma …
2023年7月7日 · In this Review, we discuss the key features of type 2 inflammation in asthma, summarize the clinical trial evidence of monoclonal antibody asthma treatments, and explore future avenues for targeted asthma treatment.
Biologic Therapies for Severe Asthma - The New England Journal of Medicine
2022年1月12日 · Patients with severe asthma are at increased risk for a decreased quality of life, fixed airway obstruction, hospitalization, and death. Biologics may be required to reduce the disease burden....
Innate players in Th2 and non-Th2 asthma - emerging roles for …
2024年10月14日 · Based on the specificity of T cells as the best-known driving force in airway inflammation, bronchial asthma is categorized into T helper cell (Th)2 and non-Th2 asthma. The most studied effector cells in Th2 asthma include T cells and eosinophils.
Type 2 immunity in asthma - World Allergy Organization Journal
2018年6月26日 · Th2 immunity exerts a pivotal role in asthma pathogenesis, beyond allergic sensitization. In fact, not only specific IgE in sensitized individuals but also many other environmental stimuli, such as viruses and pollutants, can trigger a Th2 response.
Spatial microniches of IL-2 combine with IL-10 to drive lung
2024年10月11日 · Spatial microniches of IL-2 in the lymph node supported the earliest Blimp-1+TH2 cells, demonstrating lymph node localization is a driver of TH2 initiation.
T helper 2 cells in asthma - PubMed
2023年6月5日 · This review provides an update of our current understanding of Th2 cells in human asthma, highlighting their many guises and functions in asthma, both pathogenic and regulatory, and how these are influenced by the tissue location and disease stage and severity.
Type 2 inflammation in asthma — present in most, absent in …
An important molecular mechanism of asthma is type 2 inflammation, which occurs in many but not all patients. In this Opinion article, I explore the role of type 2 inflammation in asthma, including lessons learnt from clinical trials of inhibitors of type 2 inflammation.
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