VLA-4 - Wikipedia
VLA-4 can be found on hematopoietic stem and progenitor cells. These cells are found in the bone marrow, as that is where they are produced, and throughout the rest of the body. VLA-4, specifically the alpha subunit, is crucial for the localization and circulation of progenitor cells.
Contribution of very late antigen-4 (VLA-4) integrin to cancer ...
2015年1月7日 · The integrin “very late antigen-4” (VLA-4) is expressed by numerous cells of hematopoietic origin and possesses a key function in the cellular immune response, e.g., by mediating leukocyte tethering, rolling, binding, and finally transmigration of the vascular wall at inflammatory sites.
VLA-4 (α4β1) engagement defines a novel activation pathway for …
2000年7月15日 · In this study, we sought to investigate the hypothesis that engagement of VLA-4 on monocytic cells by its natural ligand VCAM-1 or by anti-β 1 integrin monoclonal antibody (mAb) can trigger enhanced adhesiveness via β 2 integrins.
Essential roles of VLA-4 in the hematopoietic system
2010年3月30日 · Recent studies revealed that VLA-4 is not necessarily required for the development or maintenance of adult hematopoietic cells. On the other hand, it was proved that VLA-4 is essential for homeostasis of distribution of hematopoietic stem/progenitor cells (HSPCs) and mature lymphocytes in the body.
Analyses of VLA-4 Structure and Function | SpringerLink
The integrin VLA-4 mediates the adhesion of lymphocytes, monocytes, eosinophils and some melanoma cells to VCAM-1 on the surface of activated endothelial cells.1-7 Because the VLA- 4/VCAM-1 pathway plays a prominent role in the migration and localization of these...
VLA-4 Expression and Activation in B Cell Malignancies ... - MDPI
2020年3月23日 · Integrins such as the integrin very late antigen-4 (VLA-4; CD49d/CD29) control the localization of healthy as well as malignant B cells within the tissue, and thus determine the patterns of organ infiltration.
Integrin-directed antibody-based immunotherapy: focus on VLA-4
2021年2月9日 · In this respect, a humanized IgG4 anti-VLA-4 monoclonal antibody (specific to the α4-integrin chain of VLA-4) has been successfully applied to treat multiple sclerosis as well as inflammatory bowel disease.
We report that the BCR is also able to effectively inside–out activate the VLA-4 integrin in circulating CD49d-expressing CLL cells through an autonomous antigen-independent BCR signaling.
Aspects of VLA-4 and LFA-1 regulation that may contribute to …
2012年8月1日 · The physiological difference between the two integrins seems to be related to the function of the immune system. VLA-4 appears to be more important for innate antigen-independent immune responses, and LFA-1 for adaptive immunity.
Ex Vivo and In Vivo Evaluation of Overexpressed VLA-4 in Multiple ...
2016年4月1日 · Very-late-antigen-4 (VLA-4, α 4 β 1 integrin, CD49d/CD29) is a transmembrane adhesion receptor that plays an important role in cancer and immune responses. Enhanced VLA-4 expression has been observed in multiple myeloma (MM) cells and surrounding stroma.