约 3,040,000 个结果
在新选项卡中打开链接
  1. In sepsis, the antioxidant effects of vitamin C therapy4 may mitigate tissue injury induced by oxidative stress.5 Vitamin C cannot be synthe-sized by humans, and levels are low in many critically ill patients, which has increased the plausibility of benefit with supplementation.6 Af-ter a single-center study spurred interest in the use of intravenous vitamin C, administered with hydrocortisone and thiamine,7 subsequent ran-domized, controlled trials evaluating this com-bination treatment did not show benefits.8,9 In contrast, in a randomized, controlled trial, pa-tients with sepsis and acute lung injury who received a higher dose of vitamin C (50 mg per kilogram of body weight every 6 hours) had a lower 28-day risk of death than those who re-ceived placebo.10 However, recent meta-analyses suggest that the overall evidence supporting the use of vitamin C therapy in patients with sepsis is of low certainty.8,11 In the phase 3, multicenter, randomized, controlled Lessening Organ Dysfunction with Vitamin C (LOVIT) trial, we tested the hypoth-esis that a high dose of vitamin C would reduce the risk of death or persistent organ dysfunc-tion at 28 days in adults with sepsis who were receiving vasopressor therapy in the intensive care unit (ICU).
    www.nejm.org/doi/pdf/10.1056/NEJMoa2200644?articleTools=true
    www.nejm.org/doi/pdf/10.1056/NEJMoa2200644?articleTools=true
    这是否有帮助?
  2. 其他用户还问了以下问题
  3. Intravenous Vitamin C in Adults with Sepsis in the Intensive Care Unit

  4. Intravenous vitamin C therapy in adult patients with sepsis: A …

  5. vitamin c in intensive care unit 的研究
  6. Intravenous vitamin C monotherapy in critically ill patients: a ...

  7. Intravenous vitamin C in adults with sepsis in the intensive care …

  8. Vitamin C in sepsis | Intensive Care Medicine - Springer

  9. Effect of intravenous vitamin C on adult septic patients: …

    2023年8月2日 · Background: An increasing number of studies indicate that vitamin C (VC) reduces the mortality of adult septic patients, while some articles suggest otherwise. We performed this systematic review and meta-analysis to …

  10. LOVIT - Wiki Journal Club

  11. Restrictive fluid therapy and high-dose vitamin C in sepsis

  12. Intravenous vitamin C therapy in adult patients with sepsis