In 1937, an antibody was observed in horses hyper-immunized with pneumococcus polysaccharide that was much larger in size than the typical rabbit γ-globulin, with a … 展开

IgM interacts with several other physiological molecules:
1. IgM can bind complement component C1 and activate the classical pathway, leading to opsonization of antigens and cytolysis.
2. IgM binds … 展开

IgM is the first immunoglobulin expressed in the human fetus (around 20 weeks) and phylogenetically the earliest antibody to develop. 展开

• Immunoglobulin+M at the U.S. National Library of Medicine Medical Subject Headings (MeSH)
• Immunoglobulin M Deficiency Reference from Medscape.com 展开

Immunoglobulins are composed of light chains and heavy chains. The light chain (λ or κ) is a protein of ~220 amino acids, composed of a variable … 展开

In germ-line cells (sperm and ova) the genes that will eventually encode immunoglobulins are not in a functional form (see 展开

• Immunodeficiency with hyper-immunoglobulin M
• Immunoglobulin M deficiency
• Immune system 展开