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  1. Wikipedia
    https://en.wikipedia.org/wiki/Immunoglobulin_M

    Immunoglobulin M - Wikipedia

    • Immunoglobulin M (IgM) is the largest of several isotypes of antibodies (also known as immunoglobulin) that are produced by vertebrates. IgM is the first antibody to appear in the response to initial exposure to an antigen; causing it to also be called an acute phase antibody. In humans and other mammals that have been studied, plasmablasts in the spleen are th… 展开

    History

    In 1937, an antibody was observed in horses hyper-immunized with pneumococcus polysaccharide that was much larger in size than the typical rabbit γ-globulin, with a molecular weight of 990,000 daltons. In accordance with … 展开

    Structure

    Immunoglobulins are composed of light chains and heavy chains. The light chain (λ or κ) is a protein of ~220 amino acids, composed of a variable domain, VL (a segment of approximately 110 amino acids), and a co… 展开

    Biochemistry, Immunoglobulin M - StatPearls - NCBI Bookshelf
    Monomeric IgM and IgD serve as the BCRs for resting B lymphocytes that antigen recognition has not stimulated. Upon recognizing antigen, pentameric IgM is the initial antibody secreted by …
    National Center for Biotechnology Information
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  1. monomeric igm 的研究
  2. National Center for Biotechnology Information
    https://www.ncbi.nlm.nih.gov/books/NBK555995

    Biochemistry, Immunoglobulin M - StatPearls - NCBI …

    2022年12月19日 · Monomeric IgM and IgD serve as the BCRs for resting B lymphocytes that antigen recognition has not stimulated. Upon recognizing …

    • 作者: Abha Sathe, John K. Cusick
    • 已发布: 2022/12/19
    • Publish Year: 2021
  3. Nature
    https://www.nature.com/articles/s41467-022-34090-2

    Cryomicroscopy reveals the structural basis for a flexible ... - Nature

    标记:
    Nature
    Qu Chen
  4. Frontiers
    https://www.frontiersin.org/journals/imm…

    Immunoglobulin M: An Ancient Antiviral Weapon – …

    2020年8月10日 · Monomeric IgM is mostly expressed as a surface-bound receptor on B cells, and it is essential for B-cell development. When secreted, IgMs are predominantly polymers in healthy individuals. However, monomeric …

    标记:
    Igm Cells
    Immunoglobulin M
    Ancient, My Enemy
  5. PubMed
    https://pubmed.ncbi.nlm.nih.gov/32310455

    Biochemistry, Immunoglobulin M - PubMed

    标记:
    Immunoglobulin M Igm
    Immune System
    Abha Sathe, John K. Cusick
  6. National Center for Biotechnology Information
    https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7432194

    Immunoglobulin M: An Ancient Antiviral Weapon – Rediscovered

    标记:
    Immunoglobulin M Igm
    Ancient, My Enemy
    Publish Year:2020
  7. Nature
    https://www.nature.com/articles/s41586-023-05835-w

    Immunoglobulin M perception by FcμR - Nature

    标记:
    Immunoglobulin M
    Nature
  8. nih.gov
    https://pmc.ncbi.nlm.nih.gov/articles/PMC7709107

    Structure, Function, and Therapeutic Use of IgM Antibodies

    标记:
    Immunoglobulin M Igm
    Igm Function
  9. ScienceDirect
    https://www.sciencedirect.com/topics/immunology...

    Immunoglobulin M - an overview | ScienceDirect Topics

    标记:
    Igm Cells
    Igm Function
    Immune System
    Blood Test Immunoglobulin M
  10. Cell Press
    https://www.cell.com/iscience/fulltext/S258…

    B cell extracellular vesicles contain monomeric IgM …

    2023年9月15日 · We found that B cells from multiple cell lines and primary B cells produce EVs that display monomeric IgM on the surface and contain encapsulated monomeric IgM, which is independent of secreted pentameric …

    标记:
    Igm Cells
    Extracellular
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