What is the ACE2 receptor? - American Society for Biochemistry …
2020年5月16日 · ACE2 helps modulate the many activities of a protein called angiotensin II (ANG II) that increases blood pressure and inflammation, increasing damage to blood vessel linings …
Angiotensin-converting enzyme 2 - Wikipedia
Given its role as the SARS-CoV-2 entry receptor, it has been repeatedly hypothesised that population variation in ACE2 may contribute to an individual's genetic susceptibility to COVID-19.
Understanding the role of ACE-2 receptor in pathogenesis of …
The recent pandemic of COVID-19 has attracted the attention of numerous researchers on ACE2 receptors, where the causative viral particle, SARS-CoV-2, is established to exploit these …
Mechanisms of SARS-CoV-2 entry into cells - Nature
2021年10月5日 · SARS-CoV-2 relies on its obligate receptor, angiotensin-converting enzyme 2 (ACE2), to enter cells 2,3,4,5,6; ACE2 was originally identified in 2003 as the receptor for …
ACE2 and ACE: structure-based insights into mechanism, regulation …
As the scale of the 2020 SARS-CoV-2 pandemic widened, it became increasingly important to understand the interaction of its spike protein with its receptor ACE2, and subsequently there …
ACE2, Much More Than Just a Receptor for SARS-COV-2
2020年6月5日 · The angiotensin converting enzyme-2 (ACE-2) has been identified as the receptor for the SARS-CoV-2 viral entry. As such, it is now receiving renewed attention as a potential …
Angiotensin-converting enzyme 2 is a functional receptor for
2003年11月27日 · Moreover, syncytia formation and viral replication were specifically inhibited by an anti-ACE2 antibody. These data demonstrate that ACE2 is a functional receptor for SARS …
Expression pattern and function of SARS-CoV-2 receptor ACE2
Angiotensin-converting enzyme 2 (ACE2), as a receptor mediating the cellular entry of SARS-CoV-2, has become a hot spot for researchers. Here, we summarized the recent progresses …
ACE2, From the Kidney to SARS-CoV-2: Donald Seldin Award …
1 天前 · Membrane-bound ACE2 is also the essential receptor for severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2). Soluble ACE2 proteins have been studied as a way …
Angiotensin-converting enzyme 2—at the heart of the COVID-19 …
2023年2月1日 · In summary, ACE2 is the critical entry receptor for all known and, by extension, all future SARS-CoV-2 variants, placing ACE2 at the heart of the COVID-19 pandemic.