Aconitase - Wikipedia
Aconitase (aconitate hydratase; EC 4.2.1.3) is an enzyme that catalyses the stereo-specific isomerization of citrate to isocitrate via cis-aconitate in the tricarboxylic acid cycle, a non-redox-active process.
Aconitase - an overview | ScienceDirect Topics
Aconitase is an enzyme that contains iron-sulfur clusters (4 Fe-4 S). Superoxide can inactivate Fe-S cluster enzymes, a process that is readily reversible. Decreases in aconitase activity that are chemically reversible are used to monitor superoxide production in cells.
ACO1 Gene - GeneCards | ACOHC Protein | ACOHC Antibody
2024年12月9日 · The protein encoded by this gene is a bifunctional, cytosolic protein that functions as an essential enzyme in the TCA cycle and interacts with mRNA to control the levels of iron inside cells. When cellular iron levels are high, this protein binds to a 4Fe-4S cluster and functions as an aconitase.
Mitochondrial Aconitase and Its Contribution to the Pathogenesis …
Aconitase (aconitate hydratase; EC 4.2.1.3) is an evolutionarily conserved enzyme of the TCA cycle. In mammalian cells, the enzyme exists in a cytosolic (Aco1) and mitochondrial (Aco2) isoform, and both isoforms carry out the isomerization of citrate to isocitrate.
Aconitase - an overview | ScienceDirect Topics
Aconitase is a mitochondrial enzyme that catalyzes the stereo-specific isomerization of citrate to isocitrate via cis-aconitate in the TCA cycle [151,152]. Aconitase is regarded as the key enzyme in citrate oxidation in human prostate epithelial cells, a unique organ that produces and releases large amounts of citrate.
Aconitase: An Iron Sensing Regulator of Mitochondrial Oxidative ...
2016年12月2日 · We now have evidence in two different human cell culture models of erythropoiesis that mitochondrial aconitase is an iron-sensing regulator of both mitochondrial respiration and erythropoiesis.
Aconitases: Non-redox Iron-Sulfur Proteins Sensitive to Reactive ...
2019年9月17日 · The cytosolic isoform of aconitase is a moonlighting enzyme; when intracellular iron is scarce, the complete disassembly of the iron-sulfur cluster occurs and apo-aconitase acquires the function of an iron responsive protein and regulates the translation of proteins involved in iron metabolism.
Mitochondrial aconitase suppresses immunity by modulating …
2023年6月22日 · Here we show that mitochondrial aconitase, ACO-2, a Krebs cycle enzyme that catalyzes the conversion of citrate to isocitrate, inhibits immunity against pathogenic bacteria in C. elegans.
CDD Conserved Protein Domain Family: Aconitase - National …
Aconitase (aconitate hydratase) catalyzes the reversible isomerization of citrate and isocitrate as part of the TCA cycle. Cis-aconitate is formed as an intermediate product during the course of the reaction.
Aconitase: To Be or not to Be Inside Plant Glyoxysomes, That Is …
2020年7月12日 · After the discovery in 1967 of plant glyoxysomes, aconitase, one the five enzymes involved in the glyoxylate cycle, was thought to be present in the organelles, and although this was found not to be the case around 25 years ago, it is still suggested in some textbooks and recent scientific articles.
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