Antifungal Agents - Medical Microbiology - NCBI Bookshelf
This chapter summarizes the more common antifungal agents. Three groups of drugs are emphasized: the polyenes, the azoles, and one antimetabolite.Table 76-1 summarizes the most important antifungal agents and their most common uses.
Antifungal Agents: Mode of Action, Mechanisms of Resistance, …
Antifungals can be grouped into three classes based on their site of action: azoles, which inhibit the synthesis of ergosterol (the main fungal sterol); polyenes, which interact with fungal membrane sterols physicochemically; and 5-fluorocytosine, …
Antifungals: What They Treat, How They Work & Side Effects
2021年7月26日 · Antifungal medicines treat fungal infections. Fungus in the soil, air and on your skin can cause yeast infections, ringworm, and nail and skin infections. Breathing in fungal spores can lead to respiratory illnesses. People who have weak immune systems are more prone to fungal infections that require antifungal medicine. What are antifungals?
Antifungal Agents: Spectrum of Activity, Pharmacology, and …
The currently available antifungal therapies vary significantly in terms of spectrum of activity, pharmacologic properties, toxicity, and potential for drug-drug interactions. This article provides a history of antifungal development and discusses the …
Antifungal Antibiotics - StatPearls - NCBI Bookshelf
2023年3月7日 · Mechanistically, antifungal agents are diverse, yet due to the alarming and rapid increase in drug-resistant systemic fungal infections, new agents are necessary more than ever. [6] [7] [8] [9] This discussion will focus on the currently available antifungal agents. [10] …
Antifungal Medications: Types, How They Work, and More - Healthline
2019年12月6日 · Antifungal drugs are used to treat fungal infections. They target processes and structures unique to fungi in order to kill fungal cells or prevent them from growing.
Antifungal Medications - Antifungal Medications - The Merck …
These drugs are potently fungicidal against most clinically important Candida species (see treatment of invasive candidiasis) but are considered fungistatic against Aspergillus. Adverse effects of echinocandins include hepatitis and rash.
Antifungal Drugs - PMC
We reviewed the licensed antifungal drugs and summarized their mechanisms of action, pharmacological profiles, and susceptibility to specific fungi. Approved antimycotics inhibit 1,3-β-d-glucan synthase, lanosterol 14-α-demethylase, protein, and ...
Antifungal agents: mechanisms of action - ScienceDirect
2003年6月1日 · There are six new antifungal agents that are currently generating excitement as they pass through the final developmental stages of clinical trials. Three of them (posaconazole, ravuconazole and voriconazole) are triazole compounds, a subset of the azoles, which are the most successful antifungal class in the clinic since the late 1960s.
Molecular mechanisms governing antifungal drug resistance
2023年7月17日 · In this review, we discuss the diverse strategies employed by leading fungal pathogens to evolve antifungal resistance, including drug target alterations, enhanced drug efflux, and induction of...