Bilirubin metabolism - UpToDate
2023年9月5日 · Bilirubin is the catabolic product of heme metabolism. Within the physiologic range, bilirubin has cytoprotective and beneficial metabolic effects, but at high levels it is potentially toxic. Fortunately, there are elaborate physiologic …
Bilirubin metabolism - UpToDate
2022年10月24日 · Bilirubin is the catabolic product of heme metabolism. Within physiologic range, bilirubin has cytoprotective and beneficial metabolic effects, but in high levels it is potentially toxic. Fortunately, there are elaborate physiologic mechanisms for its detoxification and disposition.
Bilirubin metabolism - UpToDate - Wolters Kluwer
2023年9月5日 · Bilirubin is the catabolic product of heme metabolism. Within the physiologic range, bilirubin has cytoprotective and beneficial metabolic effects, but at high levels it is potentially toxic. Fortunately, there are elaborate physiologic …
Unconjugated hyperbilirubinemia in preterm infants <35 weeks
2024年4月8日 · BILIRUBIN-INDUCED NEUROLOGIC DYSFUNCTION. Increased vulnerability due to prematurity - Hypoalbuminemia and bilirubin-binding capacity; PATHOPHYSIOLOGY; SCREENING FOR HYPERBILIRUBINEMIA. Approach to screening; Choice of screening test - Total serum/plasma bilirubin - Transcutaneous bilirubin - Other tests; CLINICAL …
Bilirubin production, metabolism, and excretion - UpToDate
Schematic diagram demonstrating the production, metabolism, and excretion of bilirubin. *Physiologic mechanisms that reduce the movement of free bilirubin across the blood-brain barrier include binding to plasma albumin and rapid uptake, conjugation, and clearance by the liver.
Gilbert syndrome - UpToDate
2023年9月5日 · Gilbert syndrome is the most common inherited disorder of bilirubin glucuronidation, with an estimated prevalence of 6 to 14 percent . Patients typically present during adolescence when alterations in sex steroid concentrations affect bilirubin metabolism, leading to increased plasma bilirubin concentrations [ 9 ].
Unconjugated hyperbilirubinemia in neonates: Etiology and
2024年9月5日 · Newborns with severe hyperbilirubinemia (defined as TSB >25 mg/dL [428 micromol/L] in term and late preterm newborns [gestational age ≥35 weeks]) are at risk for developing bilirubin-induced neurotoxicity.
Approach to the patient with abnormal liver tests - UpToDate
2024年8月30日 · Inborn errors of metabolism: Epidemiology, pathogenesis, and clinical features; Infectious mononucleosis; Inherited disorders associated with conjugated hyperbilirubinemia in adults; Intrahepatic cholestasis of pregnancy; Malnutrition in children in resource-limited settings: Clinical assessment
RELATED TOPICS - UpToDate
2023年9月5日 · The normal serum bilirubin concentration in children and adults is less than 1 mg/dL (17 micromol/liter), less than 5 percent of which is present in conjugated form. The measurement is usually made using diazo reagents and spectrophotometry.
Rhabdomyolysis: Clinical manifestations and diagnosis
2024年6月24日 · Because of its rapid excretion and metabolism to bilirubin, serum myoglobin levels may return to normal within six to eight hours after release from muscle. Thus, it is not unusual for CK levels to remain elevated in the absence of myoglobinuria . In rhabdomyolysis, myoglobin appears in the plasma before CK elevation occurs and disappears while ...