Gypenoside XVII, an Active Ingredient from Gynostemma …
Gypenosides are the main active components from Gynostemma pentaphyllum, with diverse biological activities. In our preliminary study, Gypenoside XVII, the active ingredient of Gypenosides, was isolated and screened in LPS-induced BV2 microglia.
Gypenoside - an overview | ScienceDirect Topics
2020年2月29日 · Gypenosides promote glycolipid metabolism, brown fat activity, white fat browning and β-oxidation, reduce the ratio of Firmicutes to Bacteroidetes and increase the abundance of Akkermansia species. Prevention of high-fat diet induced obesity and insulin resistance by promoting energy expenditure and modulating the gut microbiota ( Liu et al ...
Gypenoside - an overview | ScienceDirect Topics
Gypenoside (GP) is one of the most pharmacologically natural compounds of gynostemma, with neuroprotective, anticancer, antioxidant, anti-inflammatory, and anti-diabetic effects [96]. Studies have shown the potential of GP in the treatment of neurodegenerative diseases.
Gypenosides exert cardioprotective effects by promoting …
2024年6月20日 · Gypenosides (GYPs) are the primary constituents of G. pentaphyllum. Increasing evidence indicates that GYPs are effective at preserving mitochondrial homeostasis and preventing heart failure (HF). This study aimed to uncover the cardioprotective mechanisms of GYPs related to mitochondrial regulation.
Gypenosides, the cancer buster from Gynostemma pentaphyllum (Thunb ...
2016年6月28日 · It has been extensively studied in the past 20 years and the major secondary metabolites, gypenosides (Gyp) are known to exhibit many medicinal properties such as anti-cancers, anti-inflammatory, antipyretic, anti-hyperlipidemic, and anti-diabetic.
Natural gypenosides: targeting cancer through different …
2019年3月27日 · Gypenosides (Gyp) inhibit invasion, migration, metastasis, and proliferation and induce apoptosis in different cancers, including oral, lung, colorectal, hepatocellular, and leukemic cancers through different molecular pathways.
Gypenosides Inhibit Inflammatory Response and Apoptosis of …
Severe inflammatory response leads to poor prognosis of acute lung injury (ALI), the role of gypenosides (GPs) on ALI is not fully clear. The study aimed at investigating the effects of GPs on ALI. We firstly established LPS-induced ALI mice model. ...
Uncovering the anti-NSCLC effects and mechanisms of gypenosides …
2021年12月5日 · Eleven gypenosides were detected by HPLC-MS. Gypenosides could suppress the proliferation of A549 cells, inhibit the migration of A549 cells, induce apoptosis and arrest cell cycle in G0/G1 phase.
Neuroprotective Effects of Gypenosides and Their Underlying
2023年6月16日 · In recent years, abundant research has revealed that gypenosides play a prominent role in protecting nerve cells in stroke, traumatic brain injury, Alzheimer’s disease, Parkinson’s disease, depression and other neurological disorders.
Mechanism of action of gypenosides on type 2 diabetes and …
2015年2月2日 · Gypenosides (GPs), the saponin extract derived from the herb G. pentaphyllum Makino, are believed to be one of the most pharmacologically active components in G. pentaphyllum. GPs primarily exist as dammarane type-triterpene glycosides (Figure. 1 ).
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