HIF1A - Wikipedia
HIF1A is a subunit of HIF-1, a heterodimeric protein that regulates gene expression in low oxygen conditions. HIF1A is involved in angiogenesis, metabolism, cell survival, and tumorigenesis, and is regulated by post-translational modifications and oxygen levels.
Biology of HIF-1α | Cell Death & Differentiation - Nature
Feb 15, 2008 · Molecular Biology of Hypoxia-Inducible Factor 1 (HIF-1) Investigation of the molecular mechanisms of one of the most striking responses to hypoxia – the induction of the hematopoietic growth...
Hypoxia-Inducible Factor 1-Alpha (HIF-1α): An Essential …
Jul 4, 2024 · HIF-1α can function as a multifunctional supplement for hypoxia since it regulates hypoxic genes and the environment, including angiogenesis, erythropoiesis, and glycolysis [3].
Hypoxia-Inducible Factor (HIF)-1 Regulatory Pathway and its …
One important HIF-1 function is to promote angiogenesis; HIF-1 directs migration of mature endothelial cells toward a hypoxic environment [2,5]. This is done via HIF-1 regulation of vascular endothelial growth factor (VEGF) transcription.
HIF-1 α pathway: role, regulation and intervention for cancer …
Jun 6, 2015 · Hypoxia-inducible factor-1 (HIF-1) has been recognized as an important cancer drug target. This review summarizes the role and regulation of the HIF-1α in cancer and recent therapeutic approaches targeting this important pathway.
The effect of HIF on metabolism and immunity - Nature
Jun 20, 2022 · Hypoxia increases hypoxia-inducible factor (HIF) activity, which affects the phenotype and function of innate and adaptive immune cells, including epithelial cells, neutrophils, macrophages ...
The roles of HIF-1α signaling in cardiovascular diseases
Aug 30, 2022 · In the presence of oxygen, hypoxia inducible factor (HIF)-1α protein is hydroxylated by HIF-prolyl hydroxylase (HIF-PH) and degraded via ubiquitin-proteasome dependent pathway. HIF-PH inhibitor stabilizes and activates HIF-1α signaling.
Hypoxia-inducible factor (HIF-1)α: its protein stability and …
Feb 1, 2004 · Hypoxia-inducible factor (HIF-1) is an oxygen-dependent transcriptional activator, which plays crucial roles in the angiogenesis of tumors and mammalian development. HIF-1 consists of a...
Hypoxia-inducible factor-1: Regulatory mechanisms and drug …
Jan 15, 2024 · Hypoxia-inducible factor-1 (HIF-1), a crucial regulator of hypoxia, plays a significant role in of the development of MI by modulating the behavior of various cells such as cardiomyocytes, endothelial cells, macrophages, and fibroblasts under hypoxic conditions.
Hypoxia, hypoxia-inducible factors and inflammatory bowel …
Apr 17, 2024 · HIF has a protective role in promoting intestinal epithelial barrier function in IBD. HIF-1 is expressed focally (epithelial cells, stromal fibroblasts, and myocytes) in both UC and CD, whereas HIF-2α is expressed focally in UC and diffusely in CD. The role of hypoxia in the pathogenesis of UC is different from that in CD.