The role of IL-22 in intestinal health and disease - PMC
2020年3月2日 · IL-22 is a pleiotropic cytokine that acts in the regulation of host defense, barrier function, and metabolism. This review is focused on its physiological role in mucosal tissues in health and disease.
IL-22, a vital cytokine in autoimmune diseases - PubMed
2024年4月24日 · Interleukin-22 (IL-22) is a vital cytokine that is dysregulated in various autoimmune conditions including rheumatoid arthritis (RA), multiple sclerosis (MS), and Alzheimer's disease (AD).
Therapeutic opportunities of the IL-22–IL-22R1 system
2013年12月31日 · Here, the authors describe the biology of IL-22 and highlight the therapeutic potential of modulating the activity of IL-22 and/or its receptor IL-22R1.
The tissue protective functions of interleukin-22 can be decoupled …
2021年4月13日 · The IL-22 variant 22-B3 elicited distinct STAT1 and STAT3 agonist profiles across tissue types in vitro and in vivo, behaving as a weak STAT3-biased agonist in the pancreas, a strong STAT3-biased agonist in the colon, and a neutral antagonist of STAT1 and STAT3 in the liver (Figure 5J). These results suggest that the distinct STAT1/3 activation ...
Interleukin-22 alleviates metabolic disorders and restores mucosal ...
2014年8月6日 · IL-22 shows diverse metabolic benefits, as it improves insulin sensitivity, preserves gut mucosal barrier and endocrine functions, decreases endotoxaemia and chronic inflammation, and regulates...
The role of interleukin-22 in lung health and its therapeutic …
2022年7月27日 · Interleukin-22 (IL-22) has attracted great interest over recent years, making it one of the best-studied cytokines of the interleukin-10 (IL-10) family (10, 11). The function of IL-22 is mediated through directly interacting with its heterodimeric IL-22R1 and IL-10R2 receptor complex (12, 13).
Current Knowledge of Th22 Cell and IL-22 Functions in Infectious ...
2023年1月23日 · The main effector molecule secreted by Th22 cells is IL-22, a member of the IL-10 family, which acts by binding to IL-22R and triggering a complex downstream signaling system. Th22 cells and IL-22 have been found to play variable roles in human immunity.
Interleukin-22: a potential therapeutic target in atherosclerosis
2021年8月13日 · In this review, we focus on the latest advance regarding the regulation and signaling pathways of IL-22 and highlight its impacts on atherosclerosis. IL-22, an important member of the IL-10 family of cytokines, is released by cells of the adaptive and innate immune system and plays a key role in the development of inflammatory diseases.
Interleukin-22 from bench to bedside: a promising drug for
2018年6月19日 · In general, IL-22 protects against epithelial cell injury and reduces bacterial infection, thereby inhibiting inflammation. 6,7,12 However, IL-22 has also been implicated in promoting...
Recent advances in IL-22 biology - PubMed
T(h)22 cells produce IL-22 in response to IL-6 and tumor necrosis factor α (TNF-α), particularly in the skin, whereas γδ T cells produce IL-22 in response to IL-23, particularly in the lung. NK cells produce IL-22 in response to IL-12 and IL-18 or IL-23.
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