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Levinthal's paradox is a thought experiment in the field of computational protein structure prediction; protein folding seeks a stable energy configuration. An algorithmic search through all possible conformations to identify the minimum energy configuration (the native state) would take an immense … 展开
In 1969, Cyrus Levinthal noted that, because of the very large number of degrees of freedom in an unfolded polypeptide chain, the molecule has an astronomical number of … 展开
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• 展开According to Edward Trifonov and Igor Berezovsky, the proteins fold by subunits (modules) of the size of 25–30 amino acids. 展开
• Chaperone – proteins that assist other proteins in folding or unfolding
• Folding funnel
• Anfinsen's dogma 展开CC-BY-SA 许可证中的维基百科文本 利文索尔佯谬 - 维基百科，自由的百科全书
Introducing the Levinthal’s Protein Folding Paradox …
2014年8月4日 · The protein folding (Levinthal’s) paradox states that it would not be possible in a physically meaningful time to a protein to reach the native (functional) conformation by a random search of the enormously large number …
Levinthal's Paradox - (Molecular Biology) - Fiveable
Levinthal's Paradox has profoundly impacted our understanding of molecular biology by emphasizing the complexity and efficiency inherent in protein folding processes. It has led to …
Protein folding problem: enigma, paradox, solution
This article reviews the current understanding of protein folding kinetics, including the Levinthal's paradox, which is the challenge of how a protein chain can find its native structure in a …
Levinthal's paradox. - PMC - National Center for Biotechnology …
2001年1月1日 · Levinthal's paradox is that finding the native folded state of a protein by a random search among all possible configurations can take an enormously long time. Yet proteins …
The Levinthal paradox: yesterday and today - ScienceDirect
1997年6月1日 · The Levinthal paradox [11] dominated ideas about protein folding until very recently. The essential concept introduced by Levinthal is that the appropriate point of …
Levinthal's paradox - PubMed
2001年1月1日 · Levinthal's paradox is that finding the native folded state of a protein by a random search among all possible configurations can take an enormously long time. Yet proteins …
Solution of Levinthal's Paradox and a Physical Theory of Protein ...
2020年2月6日 · We will discuss in this review the key ideas and discoveries leading to the current understanding of folding kinetics, including the solution of Levinthal's paradox, as well as the …
analysis of Levinthal's paradox for a highly simplified model of protein folding. A first-passage time calculation shows that for an unbiased random search, Levinthal's protein folding …
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