Natural killer cell therapies - Nature
2024年2月21日 · The monoclonal-antibody-based NK therapies encompass the activation of NK cell antitumour immunity using immune checkpoint inhibitors (red antibodies) such as anti-LAG3, anti-NKG2A,...
Molecular mechanisms of natural killer cell activation in ...
2013年4月12日 · NK Cell-Mediated Recognition of Cellular Stress by NKG2D and DNAM-1. NKG2D is a lectin-like type 2 transmembrane receptor expressed as a homodimer in both mice and humans by virtually all...
Human NK cells: From development to effector functions
2021年3月24日 · Functions of NK cells. (A) NK cells suppress GvHD by directly killing T cells or by indirectly killing APCs. Moreover, NK cells can also promote the development of GvHD through the secretion of pro-inflammatory cytokines. (B) NK cells destroy metastatic cells. (C) NK cells destroy infected or stressed cells that display up-regulated activating ...
Human NK cells: surface receptors, inhibitory checkpoints ...
2019年2月18日 · The regulation/induction of NK cell function is mediated by an array of activating or inhibitory surface receptors. In humans, major activating receptors involved in target cell killing are the...
Natural Killer Cells: Development, Maturation, and Clinical ...
2018年8月13日 · The molecular mechanisms that regulate NK cell cytotoxicity have been well described and can be divided into three main processes: (1) target cell recognition, (2) target cell contact and immunological synapse (IS) formation, and (3) NK cell-induced target cell death.
Human NK cells, their receptors and function - PMC
2021年5月10日 · During development from hematopoietic stem cells, human NK cells acquire a repertoire of activating and inhibitory receptors that regulate NK‐cell function in different tissues, contributing to immunity.
Activating and inhibitory receptors of natural killer cells
To recognize and respond to inflamed or infected tissues, NK cells express a variety of activating and inhibitory receptors including NKG2D, Ly49 or KIR, CD94-NKG2 heterodimers and natural cytotoxicity receptors, as well as co-stimulatory receptors.