Regulating Nrf2-GPx4 axis by bicyclol can prevent ferroptosis
2022年9月7日 · The underpinning mechanism pertaining to the medicinal effect of bicyclol is partially attributed to the regulation of Nrf2-GPx4 axis, which provides a therapeutic avenue for patients with ALI...
The regulation and function of Nrf2 signaling in ferroptosis …
2024年7月17日 · The key anti-oxidative transcription factor, nuclear factor E2 related factor 2 (Nrf2 or NFE2L2), plays a dominant role in defense machinery by reprogramming the iron, intermediate, and...
Nrf2-mediated ferroptosis inhibition: a novel approach for …
2024年8月10日 · Nrf2 induces the key targets of FPN1, xCT, and GPX4 inducing ferroptosis. Therefore, Nrf2 activation can treat diseases by inhibiting ferroptosis, especially for inflammatory diseases (psoriasis, AS, RA, and UC).
GPX4-independent ferroptosis—a new strategy in disease’s therapy
2022年10月30日 · It can inhibit ferroptosis by activating GPX4 by activating SLC7A11. In addition, NRF2 is regulated by the cytoplasmic inhibitor Kelch-like ECH-associating protein 1 (KEAP1).
NRF2 plays a critical role in mitigating lipid peroxidation and ...
2019年5月1日 · Two of the most critical targets whose inhibition initiates ferroptosis, xCT and GPX4, are well established to be regulated by NRF2. As such, targeting NRF2 in diseases where lipid peroxidation and ferroptosis are prevalent features remains an extremely viable approach.
Nrf2 and Ferroptosis: A New Research Direction for ... - PubMed
2020年4月21日 · Ferroptosis is a kind of regulated cell death (RCD) caused by the redox state disorder of intracellular microenvironment controlled by glutathione (GSH) peroxidase 4 (GPX4), which is inhibited by iron chelators and lipophilic antioxidants.
Targeting Nrf2 for ferroptosis-based therapy: Implications for ...
2023年10月1日 · Nrf2 controls the core regulators involved in ferroptosis, xCT, GPX4, and FSP1, which protects cells against ferroptosis by preventing lipid peroxide accumulation and lipoxidation of target proteins. Numerous downstream targets of Nrf2 are also involved in LPO and ferroptosis.
GPX4, ferroptosis, and diseases - ScienceDirect
2024年5月1日 · Nrf2 exerts direct influence on GPX4 and indirectly affects GPX4 through the generation of GSH. p53 inhibits the Xc−/GSH/GPX4 axis by suppressing SLC7A11. Additionally, several other molecules impact the progression of ferroptosis by modulating different targets within this signaling pathway.
VDR activation attenuates osteoblastic ferroptosis and ... - PubMed
2022年11月20日 · Proteomics and immunofluorescence analysis confirmed that ferroptosis and suppression of the Nrf2/GPX4 pathway occurred in VDR-knockout mice. Our data demonstrated that ferroptosis played an essential role in age-related osteoporosis.
Regulating Nrf2-GPx4 axis by bicyclol can prevent ferroptosis
2022年9月7日 · Erastin-treated L-O2 hepatocytes were transfected with glutathione peroxidase 4 (GPx4) or nuclear factor erythroid 2-related factor 2 (Nrf2) siRNA to delineate the pathway of bicyclol against ferroptosis in vitro.