Characterization of twenty-five ovarian tumour cell lines that
Jun 17, 2015 · Here, we report the phenotypic properties of 25 new ovarian cancer cell lines (OCI) derived using cell culture media optimized for human ovarian cancer subtypes (Ovarian Carcinoma Modified...
Characterization of ovarian cancer cell lines as in vivo models for ...
We introduced 18 ovarian cancer cell lines into athymic nude mice through subcutaneous, intraperitoneal, and ovary intrabursal routes, and observed tumor development over 6 weeks.
Distinct transcriptional programs stratify ovarian cancer cell lines ...
Sep 1, 2021 · NMF of RNAseq segregates ovarian cancer cell lines into five clusters that recapitulate histological subtypes. A Quality metrics describing the performance of NMF for 2 to 10 clusters. From left, the cophenetic correlation coefficients, dispersion and silhouette. Colours indicate the type of measure plotted.
Distinct transcriptional programs stratify ovarian cancer cell lines ...
Epithelial ovarian cancer (OC) is a heterogenous disease consisting of five major histologically distinct subtypes: high-grade serous (HGSOC), low-grade serous (LGSOC), endometrioid (ENOC), clear cell (CCOC) and mucinous (MOC).
Evaluating cell lines as tumour models by comparison of genomic ...
Jul 9, 2013 · We identify several rarely used cell lines that more closely resemble cognate tumour profiles than commonly used cell lines, and we propose these lines as the most suitable models of ovarian...
Nanomechanical Characterization of Ovarian Cancer Cell Lines as …
The AFM analysis of the eight ovarian cancer cell lines showed a widespread distribution of the mean Young’s modulus (from 0.28 ± 0.12 kPa for TYKNU to 1.13 ± 0.50 kPa for OVCAR4) with a statistically significant overall difference, as established by the Kruskal–Wallis test (p = …
Classification of ovarian cancer cell lines using transcriptional ...
Jul 15, 2020 · Here, we find that application of non-negative matrix factorisation (NMF) to the transcriptional profiles of 45 commonly used ovarian cancer cell lines exquisitely clusters them into five distinct classes, representative of the five main subtypes of EOC.
Characterization of ovarian cancer cell lines as in vivo ... - PubMed
We report the tumorigenicity of 17 human ovarian cancer cell lines and one mouse cell line in three distinct anatomical locations, and associated gene networks. Growth patterns and histopathology, linked to molecular characteristics, provide a valuable resource to the research community, and better …
Identification of ovarian high-grade serous carcinoma cell lines …
Jul 1, 2020 · Here, we systematically assessed in vivo growth of ovarian cancer cells, including six validated HGSC cell lines, in highly immunocompromised NSG mice by varying the injection site.
Jul 14, 2020 · selection of the most appropriate models for all five pathological subtypes of ovarian cancer. lines, we are able provide a methodology for future classification of novel EOC cell lines. and North America (Bray et al., 2018). Epithelial ovarian cancer (EOC), which accounts for 80% of. 2019).