Oct 27, 2022 · Pamprin Multi-Symptom Maximum Strength is an over-the-counter medication that contains acetaminophen (a pain reliever), pamabrom (a diuretic, or water pill), and pyrilamine (an antihistamine). It's used to treat symptoms caused by monthly menstrual periods (e.g., bloating, cramps, aches, pains, extra water weight) in people ages 12 years and older.