Pyrimidine dimer - Wikipedia
Pyrimidine dimers represent molecular lesions originating from thymine or cytosine bases within DNA, resulting from photochemical reactions. [1][2] These lesions, commonly linked to direct DNA damage, [3] are induced by ultraviolet light (UV), particularly UVC, result in the formation of covalent bonds between adjacent nitrogenous bases along th...
DNA Repair - The Cell - NCBI Bookshelf
The major type of damage induced by UV light is the formation of pyrimidine dimers, in which adjacent pyrimidines on the same strand of DNA are joined by the formation of a cyclobutane ring resulting from saturation of the double bonds between carbons 5 and 6 (see Figure 5.20A). The formation of such dimers distorts the structure of the DNA ...
Pyrimidine Dimer - an overview | ScienceDirect Topics
A pyrimidine dimer is an intrastrand DNA cross-link caused by exposure to ultraviolet light, which can block DNA replication and transcription. Various DNA repair mechanisms exist to remove pyrimidine dimers, as defects in their removal can lead to diseases and cancer in humans.
Pyrimidine Dimer - an overview | ScienceDirect Topics
Thymine dimers occur when DNA is exposed to UV radiation. The most common form, cis-syn cyclobutane pyrimidine dimer (CPD), is a strong block to replicative DNA polymerases.
9.3: DNA Repair - Biology LibreTexts
Pyrimidine Dimerization UV light exposure of DNA can cause adjacent pyrimidines (commonly thymines; less often, cytosines) on a DNA strand to dimerize. Pyrimidine dimers form at a rate of a bit less than 100 per cell per day!
Pyrimidine Dimer - an overview | ScienceDirect Topics
Pyrimidine dimers are structures that form between two of four nucleotide bases that make up DNA: the nucleotides cytosine and thymine, which are members of the chemical family called pyrimidines. From: Animal Biotechnology, 2014
7.3: Ionizing Radiation - Biology LibreTexts
2023年6月20日 · Ultraviolet radiation with a wavelength of 260 nm will form pyrimidine dimers between adjacent pyrimidines in the DNA. The dimers can be one of two types (Figure 7.11). The major product is a cytobutane-containing thymine dimer (between C5 and C6 of adjacent T's).
Pyrimidine Dimers - Illinois Experts
Pyrimidine dimer is an intrastrand DNA cross-link, induced by exposure to ultraviolet light (sunlight). Two types of dimers are formed, depending on whether DNA is single-stranded or duplex. Pyrimidine dimers block both DNA replication and transcription and have to be removed to return DNA to its functional state.
Pyrimidine dimer | C8H8N4 | CID 22057568 - PubChem
2021年10月14日 · Pyrimidine Dimer is a pair of pyrimidine bases (thymine or cytosine in DNA or uracil in double-stranded RNA) within a nucleic acid covalently linked by a cyclobutane ring, the formation of which was induced by exposure to ultraviolet radiation.
Pyrimidine - Wikipedia
Pyrimidine (C 4 H 4 N 2; / p ɪ ˈ r ɪ. m ɪ ˌ d iː n, p aɪ ˈ r ɪ. m ɪ ˌ d iː n /) is an aromatic, heterocyclic, organic compound similar to pyridine (C 5 H 5 N). [3] One of the three diazines (six-membered heterocyclics with two nitrogen atoms in the ring), it has nitrogen atoms at …
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