Macrophages: Their Untold Story in T Cell Activation and Function
Here, the role macrophages play in cancer to either activate or inhibit T cells based on macrophage phenotype, costimulatory molecules, and cytokine secretion is highlighted as an example of how macrophages can significantly alter T cell activation and effector function in human disease.
Macrophages and T cells in metabolic disorder-associated …
2024年10月1日 · Perhaps the most studied among these are the heterotypic interactions between macrophages and T cells, which hold implications for the modulation of metabolic disorder-associated cancers.
Immunotherapy-activated T cells recruit and skew late ... - Cell Press
2024年5月16日 · van Elsas et al. demonstrate that immunotherapy-induced intratumoral CD8+ T cells attract macrophages into their close vicinity via CCR5-signaling and subsequently differentiate them toward a late-stage activated M1-like phenotype.
Regulatory T cell and macrophage crosstalk in acute lung
2023年1月16日 · Two classical anti-inflammatory cell types, regulatory T cells (Tregs) and M2 macrophages, are theoretically capable of resisting uncontrolled inflammation. Recent studies have indicated...
Macrophages: Their Untold Story in T Cell Activation and Function
2019年1月1日 · Successful interactions between T cells and APCs, including macrophages, at signals 1, 2, and 3 are required to activate T cells to produce cytokines as well as induce their clonal expansion and differentiation into effector T lymphocytes.
JAK-STAT signaling maintains homeostasis in T cells and macrophages
2024年4月24日 · Baseline JAK-STAT signaling was detected in CD8+ T cells and macrophages of unperturbed mice—but abrogated in the knockouts and in unstimulated immune cells deprived of their normal tissue...
T Cells and MHC Proteins - Molecular Biology of the Cell - NCBI …
Effector helper T cells, by contrast, help stimulate the responses of other cells—mainly macrophages, B cells, and cytotoxic T cells. In this section, we describe these two classes of T cells and their respective functions.
Metabolic and Epigenetic Coordination of T Cell and Macrophage Immunity
In this review, we discuss recent studies of T cells and macrophages supporting a role for metabolic activity in integrating environmental signals with activation-induced gene-expression programs through modulation of the epigenome and speculate as to how this may influence context-specific macrophage and T cell responses to infection.
T cell–macrophage interactions and granuloma formation in …
2014年9月11日 · Interactions between macrophages and T cells are critical in the communication between innate and adaptive immunity. Errors in this interaction may result in immunodeficiency, failure to destroy invading pathogens, or damage to host–tissues in the form of autoimmunity.
Multi-scale modeling of macrophage—T cell interactions within …
2020年12月23日 · In this study, we develop an agent-based model consisting of the interactions between macrophages, T cells, and tumor cells to determine how the immune response changes due to three macrophage-based immunotherapeutic strategies: macrophage depletion, recruitment inhibition, and macrophage reeducation.