Trained immunity — basic concepts and contributions to
2022年10月17日 · Trained immunity is a functional state of the innate immune system that is characterized by long-term epigenetic and metabolic reprogramming of cells associated with potent immune responses.
Defining trained immunity and its role in health and disease
2020年3月4日 · Here we define ‘trained immunity’ as a biological process and discuss the innate stimuli and the epigenetic and metabolic reprogramming events that shape the induction of trained immunity.
Trained immunity - Wikipedia
Trained immunity is a long-term functional modification of cells in the innate immune system which leads to an altered response to a second unrelated challenge. [1] For example, the BCG vaccine leads to a reduction in childhood mortality caused by unrelated infectious agents. [2]
Trained immunity, tolerance, priming and differentiation: distinct ...
2020年12月8日 · Trained immunity has emerged as a focal point in immunology research and has added a layer of complexity to our previous understanding of immune memory, that is, a trait limited to antigen ...
Trained immunity: A program of innate immune memory in …
2016年4月22日 · Trained immunity is orchestrated by epigenetic reprogramming, broadly defined as sustained changes in gene expression and cell physiology that do not involve permanent genetic changes such as mutations and recombination, which are essential for adaptive immunity.
Trained Immunity: Reprogramming Innate Immunity in Health …
2021年4月26日 · Trained immunity is characterized by nonspecific increased responsiveness, mediated via extensive metabolic and epigenetic reprogramming. Trained immunity explains the heterologous effects of vaccines, which result in …
Trained immunity: A “new” weapon in the fight against infectious ...
2023年3月13日 · Here, we present recent works bridging trained immunity and infectious disease that raise important discoveries, questions, concerns, and novel avenues for the modulation of trained immunity in practice.
Defining trained immunity and its role in health and disease
2020年3月4日 · Trained immunity is relevant to a range of conditions in which an exacerbated immune response drives disease progression, such as in inflammatory bowel disease, gout, allergy and atherosclerosis and its clinical consequences, namely myocardial infarction and …
Trained immunity: General and emerging concepts - PubMed
In this review, we present the latest advancements in the field of innate immune memory followed by a description of the fundamental mechanisms underpinning trained immunity generation and different cell types that mediate it.
Trained immunity - basic concepts and contributions to
Trained immunity is a functional state of the innate immune response and is characterized by long-term epigenetic reprogramming of innate immune cells.